CDHR2_HUMAN » Cadherin-related family member 2

CDHR2_HUMAN » Cadherin-related family member 2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CDHR2_HUMAN » Cadherin-related family member 2 » Protocadherin LKC;PC-LKC; Protocadherin-24;
Hydrophobic Thickness 36.0 ± 3.8 Å
Tilt Angle 35 ± 1°
ΔGtransfer -32.0 kcal/mol
ΔGfold -27.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 1148-1177 (1147-1181)
Pathways none
PDB none
OPM none
Complexes none
Interactions

CDHR5, Complex: CDHR2:CDHR5, PubMed

Domains

AA: 31-115, PDBID: 2WBX, Subunit A, Seq Identity:53%, Cadherin domain

AA: 129-225, PDBID: 2WCP, Subunit A, Seq Identity:26%, Cadherin domain

AA: 246-342, PDBID: 4ZI8, Subunit B, Seq Identity:33%, Cadherin domain

AA: 485-577, PDBID: 4ZPL, Subunit A, Seq Identity:40%, Cadherin domain

AA: 590-686, PDBID: 4ZPL, Subunit A, Seq Identity:28%, Cadherin domain

AA: 700-799, PDBID: 4ZPL, Subunit A, Seq Identity:27%, Cadherin domain

AA: 935-1041, PDBID: 2O72, Subunit A, Seq Identity:27%, Cadherin domain

UniProt annotation for CDHR2_HUMAN » Cadherin-related family member 2
FUNCTION: Role in contact inhibition at the lateral surface of epithelial cells.

SUBUNIT: Interacts with MAST2.

TISSUE SPECIFICITY: Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers.

UniProt features for CDHR2_HUMAN » Cadherin-related family member 2
SIGNAL 1 20 Potential.
CHAIN 21 1310 Cadherin-related family member 2.
DOMAIN 27 124 Cadherin 1.
DOMAIN 125 241 Cadherin 2.
DOMAIN 242 353 Cadherin 3.
DOMAIN 368 480 Cadherin 4.
DOMAIN 481 586 Cadherin 5.
DOMAIN 586 695 Cadherin 6.
DOMAIN 696 808 Cadherin 7.
DOMAIN 810 928 Cadherin 8.
DOMAIN 930 1058 Cadherin 9.
Amino Acid Sequence for CDHR2_HUMAN » Cadherin-related family member 2
MAQLWLSCFL LPALVVSVAA NVAPKFLANM TSVILPEDLP VGAQAFWLVA EDQDNDPLTY GMSGPNAYFF AVTPKTGEVK LASALDYETL YTFKVTISVS DPYIQVQREM LVIVEDRNDN APVFQNTAFS TSINETLPVG SVVFSVLAVD KDMGSAGMVV YSIEKVIPST GDSEHLFRIL ANGSIVLNGS LSYNNKSAFY QLELKACDLG GMYHNTFTIQ CSLPVFLSIS VVDQPDLDPQ FVREFYSASV AEDAAKGTSV LTVEAVDGDK GINDPVIYSI SYSTRPGWFD IGADGVIRVN GSLDREQLLE ADEEVQLQVT ATETHLNIYG QEAKVSIWVT VRVMDVNDHK PEFYNCSLPA CTFTPEEAQV NFTGYVDEHA SPRIPIDDLT MVVYDPDKGS NGTFLLSLGG PDAEAFSVSP ERAVGSASVQ VLVRVSALVD YERQTAMAVQ VVATDSVSQN FSVAMVTIHL RDINDHRPTF PQSLYVLTVP EHSATGSVVT DSIHATDPDT GAWGQITYSL LPGNGADLFQ VDPVSGTVTV RNGELLDRES QAVYYLTLQA TDGGNLSSST TLQIHLLDIN DNAPVVSGSY NIFVQEEEGN VSVTIQAHDN DEPGTNNSRL LFNLLPGPYS HNFSLDPDTG LLRNLGPLDR EAIDPALEGR IVLTVLVSDC GEPVLGTKVN VTITVEDIND NLPIFNQSSY NFTVKEEDPG VLVGVVKAWD ADQTEANNRI SFSLSGSGAN YFMIRGLVLG AGWAEGYLRL PPDVSLDYET QPVFNLTVSA ENPDPQGGET IVDVCVNVKD VNDNPPTLDV ASLRGIRVAE NGSQHGQVAV VVASDVDTSA QLEIQLVNIL CTKAGVDVGS LCWGWFSVAA NGSVYINQSK AIDYEACDLV TLVVRACDLA TDPGFQAYSN NGSLLITIED VNDNAPYFLP ENKTFVIIPE LVLPNREVAS VRARDDDSGN NGVILFSILR VDFISKDGAT IPFQGVFSIF TSSEADVFAG SIQPVTSLDS TLQGTYQVTV QARDRPSLGP FLEATTTLNL FTVDQSYRSR LQFSTPKEEV GANRQAINAA LTQATRTTVY IVDIQDIDSA ARARPHSYLD AYFVFPNGSA LTLDELSVMI RNDQDSLTQL LQLGLVVLGS QESQESDLSK QLISVIIGLG VALLLVLVIM TMAFVCVRKS YNRKLQAMKA AKEARKTAAG VMPSAPAIPG TNMYNTERAN PMLNLPNKDL GLEYLSPSND LDSVSVNSLD DNSVDVDKNS QEIKEHRPPH TPPEPDPEPL SVVLLGRQAG ASGQLEGPSY TNAGLDTTDL