CDHR1_HUMAN » Cadherin-related family member 1

CDHR1_HUMAN » Cadherin-related family member 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CDHR1_HUMAN » Cadherin-related family member 1 » Photoreceptor cadherin;prCAD; Protocadherin-21;
Hydrophobic Thickness 35.2 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -46.3 kcal/mol
ΔGfold -19.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 698-723 (698-728)
Pathways none
PDB none
OPM none
Complexes none
Interactions

RYK, Complex: CDHR1:RYK, PubMed

Domains

AA: 40-125, PDBID: 2WBX, Subunit A, Seq Identity:43%, Cadherin domain

AA: 140-237, PDBID: 2WCP, Subunit A, Seq Identity:33%, Cadherin domain

AA: 251-344, PDBID: 3PPE, Subunit A, Seq Identity:29%, Cadherin domain

AA: 477-567, PDBID: 2WCP, Subunit A, Seq Identity:35%, Cadherin domain

AA: 581-677, PDBID: 4NQQ, Subunit D, Seq Identity:26%, Cadherin domain

UniProt annotation for CDHR1_HUMAN » Cadherin-related family member 1
FUNCTION: Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).

SUBUNIT: Interacts with PROM1.

DISEASE: Cone-rod dystrophy 15 (CORD15) OMIM: An inherited retinal dystrophy characterized by retinal pigment deposits visible on fundus examination, predominantly in the macular region, and initial loss of cone photoreceptors followed by rod degeneration. This leads to decreased visual acuity and sensitivity in the central visual field, followed by loss of peripheral vision. Severe loss of vision occurs earlier than in retinitis pigmentosa. disease is caused by mutations affecting the gene represented in this entry.

UniProt features for CDHR1_HUMAN » Cadherin-related family member 1
SIGNAL 1 19 Potential.
CHAIN 20 859 Cadherin-related family member 1.
DOMAIN 36 135 Cadherin 1.
DOMAIN 136 246 Cadherin 2.
DOMAIN 247 353 Cadherin 3.
DOMAIN 359 472 Cadherin 4.
DOMAIN 473 576 Cadherin 5.
DOMAIN 573 688 Cadherin 6.
Amino Acid Sequence for CDHR1_HUMAN » Cadherin-related family member 1
MRRCRWAALA LGLLRLCLAQ ANFAPHFFDN GVGSTNGNMA LFSLPEDTPV GSHVYTLNGT DPEGDPISYH ISFDPSTRSV FSVDPTFGNI TLVEELDRER EDEIEAIISI SDGLNLVAEK VVILVTDAND EAPRFIQEPY VALVPEDIPA GSIIFKVHAV DRDTGSGGSV TYFLQNLHSP FAVDRHSGVL RLQAGATLDY ERSRTHYITV VAKDGGGRLH GADVVFSATT TVTVNVEDVQ DMAPVFVGTP YYGYVYEDTL PGSEVLKVVA MDGDRGKPNR ILYSLVNGND GAFEINETSG AISITQSPAQ LQREVYELHV QVTEMSPAGS PAAQATVPVT IRIVDLNNHP PTFYGESGPQ NRFELSMNEH PPQGEILRGL KITVNDSDQG ANAKFNLQLV GPRGIFRVVP QTVLNEAQVT IIVENSAAID FEKSKVLTFK LLAVEVNTPE KFSSTADVVI QLLDTNDNVP KFDSLYYVAR IPENAPGGSS VVAVTAVDPD TGPWGEVKYS TYGTGADLFL IHPSTGLIYT QPWASLDAEA TARYNFYVKA EDMEGKYSVA EVFITLLDVN DHPPQFGKSV QKKTMVLGTP VKIEAIDEDA EEPNNLVDYS ITHAEPANVF DINSHTGEIW LKNSIRSLDA LHNITPGRDC LWSLEVQAKD RGSPSFSTTA LLKIDITDAE TLSRSPMAAF LIQTKDNPMK AVGVLAGTMA TVVAITVLIS TATFWRNKKS NKVLPMRRVL RKRPSPAPRT IRIEWLKSKS TKAATKFMLK EKPPNENCNN NSPESSLLPR APALPPPPSV APSTGAAQWT VPTVSGSLTP QPTQPPPKPK TMGSPVQSTL ISELKQKFEK KSVHNKAYF