CDCP1_HUMAN » CUB domain-containing protein 1

CDCP1_HUMAN » CUB domain-containing protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CDCP1_HUMAN » CUB domain-containing protein 1 » Membrane glycoprotein gp140;Subtractive immunization M plus HEp3-associated 135 kDa protein;SIMA135; Transmembrane and associated with src kinases;
Hydrophobic Thickness 34.8 ± 5.6 Å
Tilt Angle 42 ± 5°
ΔGtransfer -23.9 kcal/mol
ΔGfold -18.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 664-689 (664-696)
Pathways none
PDB none
OPM none
Complexes none
Interactions

EGFR, Complex: CDCP1:EGFR, PubMed

ST14, Complex: CDCP1:ST14, PubMed

Domains none
UniProt annotation for CDCP1_HUMAN » CUB domain-containing protein 1
FUNCTION: May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis.

SUBUNIT: Interacts with CDH2/N-cadherin, CDH3/P-cadherin, SDC1/syndecan-1, SDC4/syndecan-4 and the serine protease ST14/MT- SP1. Also interacts with SRC and PRKCG/protein kinase C gamma.

TISSUE SPECIFICITY: Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells.

UniProt features for CDCP1_HUMAN » CUB domain-containing protein 1
SIGNAL 1 29
CHAIN 30 836 CUB domain-containing protein 1.
DOMAIN 417 544 CUB.
SITE 368 369 Cleavage; by ST14/MT-SP1.
DISULFID 476 499 By similarity.
Amino Acid Sequence for CDCP1_HUMAN » CUB domain-containing protein 1
MAGLNCGVSI ALLGVLLLGA ARLPRGAEAF EIALPRESNI TVLIKLGTPT LLAKPCYIVI SKRHITMLSI KSGERIVFTF SCQSPENHFV IEIQKNIDCM SGPCPFGEVQ LQPSTSLLPT LNRTFIWDVK AHKSIGLELQ FSIPRLRQIG PGESCPDGVT HSISGRIDAT VVRIGTFCSN GTVSRIKMQE GVKMALHLPW FHPRNVSGFS IANRSSIKRL CIIESVFEGE GSATLMSANY PEGFPEDELM TWQFVVPAHL RASVSFLNFN LSNCERKEER VEYYIPGSTT NPEVFKLEDK QPGNMAGNFN LSLQGCDQDA QSPGILRLQF QVLVQHPQNE SNKIYVVDLS NERAMSLTIE PRPVKQSRKF VPGCFVCLES RTCSSNLTLT SGSKHKISFL CDDLTRLWMN VEKTISCTDH RYCQRKSYSL QVPSDILHLP VELHDFSWKL LVPKDRLSLV LVPAQKLQQH THEKPCNTSF SYLVASAIPS QDLYFGSFCP GGSIKQIQVK QNISVTLRTF APSFRQEASR QGLTVSFIPY FKEEGVFTVT PDTKSKVYLR TPNWDRGLPS LTSVSWNISV PRDQVACLTF FKERSGVVCQ TGRAFMIIQE QRTRAEEIFS LDEDVLPKPS FHHHSFWVNI SNCSPTSGKQ LDLLFSVTLT PRTVDLTVIL IAAVGGGVLL LSALGLIICC VKKKKKKTNK GPAVGIYNGN INTEMPRQPK KFQKGRKDND SHVYAVIEDT MVYGHLLQDS SGSFLQPEVD TYRPFQGTMG VCPPSPPTIC SRAPTAKLAT EEPPPRSPPE SESEPYTFSH PNNGDVSSKD TDIPLLNTQE PMEPAE