CD99_HUMAN » CD99 antigen

CD99_HUMAN » CD99 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD99_HUMAN » CD99 antigen » 12E7;E2 antigen;Protein MIC2;T-cell surface glycoprotein E2;
Hydrophobic Thickness 29.6 ± 1.4 Å
Tilt Angle 0 ± 1°
ΔGtransfer -31.2 kcal/mol
ΔGfold -14.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 126-147 (126-152)
Pathways

Cell adhesion molecules (KEGG)

Leukocyte transendothelial migration (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 26-181, CD99 antigen like protein 2

UniProt annotation for CD99_HUMAN » CD99 antigen
FUNCTION: Involved in T-cell adhesion processes and in spontaneous rosette formation with erythrocytes. Plays a role in a late step of leukocyte extravasation helping leukocytes to overcome the endothelial basement membrane. Acts at the same site as, but independently of, PECAM1. Involved in T-cell adhesion processes (By similarity).

MISCELLANEOUS: The gene coding for this protein is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes.

UniProt features for CD99_HUMAN » CD99 antigen
SIGNAL 1 22
CHAIN 23 185 CD99 antigen.
Amino Acid Sequence for CD99_HUMAN » CD99 antigen
MARGAALALL LFGLLGVLVA APDGGFDLSD ALPDNENKKP TAIPKKPSAG DDFDLGDAVV DGENDDPRPP NPPKPMPNPN PNHPSSSGSF SDADLADGVS GGEGKGGSDG GGSHRKEGEE ADAPGVIPGI VGAVVVAVAG AISSFIAYQK KKLCFKENAE QGEVDMESHR NANAEPAVQR TLLEK