CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain

CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain
Magnify CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain »
Hydrophobic Thickness 35.6 ± 2.2 Å
Tilt Angle 26 ± 2°
ΔGtransfer -25.9 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 170-195 (170-200)
Pathways

Antigen processing and presentation (KEGG)

Cell adhesion molecules (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB none
OPM none
Complexes

CD8A:CD8B_MOUSE

CD8A:CD8B:HA12:B2MG_MOUSE

KACA:IGG2B:CD8A:CD8B_MOUSE

Interactions

CD3D, Complex: CD3D:CD8B, PubMed

CD3Z, Complex: CD3Z:CD8B, PubMed

CD8A, Complex: B2MG:CD8A:CD8B, PDBID: 3dmm

SIA4C, Complex: SIA4C:CD8B, PubMed

Domains

AA: 24-135, PDBID: 2ATP, Subunit B, Seq Identity:49%, Immunoglobulin V-set domain

UniProt annotation for CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain
FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing.

SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.

TISSUE SPECIFICITY: Isoform 1, isoform 3, isoform 5, isoform 6, isoform 7 and isoform 8 are expressed in both thymus and peripheral CD8+ T-cells. Expression of isoform 1 is higher in thymus CD8+ T-cells than in peripheral CD8+ T-cells. Expression of isoform 6 is higher in peripheral CD8+ T-cells than in thymus CD8+ T-cells.

UniProt features for CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain
SIGNAL 1 21
CHAIN 22 210 T-cell surface glycoprotein CD8 beta chain.
DOMAIN 22 132 Ig-like V-type.
DISULFID 41 116 Potential.
Amino Acid Sequence for CD8B_HUMAN » T-cell surface glycoprotein CD8 beta chain
MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK