CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain

CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain » CD8b pseudogene;
Hydrophobic Thickness 30.8 ± 2.0 Å
Tilt Angle 0 ± 3°
ΔGtransfer -39.9 kcal/mol
ΔGfold -18.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 171-196 (171-201)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-135, PDBID: 2ATP, Subunit B, Seq Identity:48%, Immunoglobulin V-set domain

UniProt annotation for CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain
FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing (By similarity).

SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds.

UniProt features for CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain
SIGNAL 1 18 Potential.
CHAIN 19 211 Putative T-cell surface glycoprotein CD8 beta-2 chain.
DOMAIN 19 132 Ig-like V-type.
DISULFID 41 116 By similarity.
Amino Acid Sequence for CD8BL_HUMAN » Putative T-cell surface glycoprotein CD8 beta-2 chain
MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM CIYWLRQRQA PSSDSHHEFL TLWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG SPELTFGKGT QLSVVVDFLP TTAQPTKKST LKKRVCRLPR PETQKGPLCS PVTLGLLVAG VLVLLVSLGV AMHLCCRRRR ARLRFMKQLY K