CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain

CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain » T-lymphocyte differentiation antigen T8/Leu-2;
Hydrophobic Thickness 30.8 ± 3.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -27.5 kcal/mol
ΔGfold -12.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 179-205 (179-212)
Pathways

Antigen processing and presentation (KEGG)

Cell adhesion molecules (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 2hp4 (A/B=22-135), 1q69 (A=209-227), 1cd8 (A=22-135), 1akj (D/E=22-141), 3qzw (G/H/I/J=22-135)
OPM none
Complexes

CD8A:1A02:B2MG_HUMAN

CD8A:1A24:Q9YYU8:B2MG_HUMAN

CD8A:CD8B_MOUSE

CD8A:CD8B:HA12:B2MG_MOUSE

KACA:IGG2B:CD8A:CD8B_MOUSE

CD8A:CD8A_HUMAN

Interactions

1A02, Complex: 1A02:B2MG:CD8A, PDBID: 1akj

1A24, Complex: CD8A:1A24:Q9YYU8:B2MG, PDBID: 3QZW

1B07, Complex: 1B07:CD8A, PubMed

1C07, Complex: 1C07:CD8A

CD3D, Complex: CD3D:CD8A, PubMed

CD8A, Complex: Homodimer of glycoprotein cd8 alpha chain, PDBID: 2HP4

CD8B, Complex: B2MG:CD8A:CD8B, PDBID: 3dmm

HLAE, Complex: HLAE:CD8A, PubMed

HLAG, Complex: CD8A:HLAG, PubMed

LAT, Complex: CD8A:LAT, PubMed

PTPRC, Complex: CD8A:PTPRC, PubMed

Domains

AA: 26-132, PDBID: 1AKJ, Subunit D, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain
FUNCTION: Identifies cytotoxic/suppressor T-cells that interact with MHC class I bearing targets. CD8 is thought to play a role in the process of T-cell mediated killing. CD8 alpha chains binds to class I MHC molecules alpha-3 domains.

SUBUNIT: In general heterodimer of an alpha and a beta chain linked by two disulfide bonds. Can also form homodimers. Shown to be expressed as heterodimer on thymocytes and as homodimer on peripheral blood T-lymphocytes. Interacts with the MHC class I HLA-A/B2M dimer. Interacts with LCK in a zinc-dependent manner.

DISEASE: CD8 deficiency, familial (CD8 deficiency) OMIM: An immunologic defect characterized by absence of CD8+ cells, leading to recurrent bacterial infections. mutations affecting the gene represented in this entry.

UniProt features for CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain
SIGNAL 1 21
CHAIN 22 235 T-cell surface glycoprotein CD8 alpha chain.
DOMAIN 22 135 Ig-like V-type.
DISULFID 43 115
Amino Acid Sequence for CD8A_HUMAN » T-cell surface glycoprotein CD8 alpha chain
MALPVTALLL PLALLLHAAR PSQFRVSPLD RTWNLGETVE LKCQVLLSNP TSGCSWLFQP RGAAASPTFL LYLSQNKPKA AEGLDTQRFS GKRLGDTFVL TLSDFRRENE GYYFCSALSN SIMYFSHFVP VFLPAKPTTT PAPRPPTPAP TIASQPLSLR PEACRPAAGG AVHTRGLDFA CDIYIWAPLA GTCGVLLLSL VITLYCNHRN RRRVCKCPRP VVKSGDKPSL SARYV