CD86_HUMAN » T-lymphocyte activation antigen CD86

CD86_HUMAN » T-lymphocyte activation antigen CD86
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Topology in Plasma membrane
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cytoplasmic side
CD86_HUMAN » T-lymphocyte activation antigen CD86 » Activation B7-2 antigen;B70;BU63;CTLA-4 counter-receptor B7.2;FUN-1;
Hydrophobic Thickness 37.2 ± 1.4 Å
Tilt Angle 1 ± 0°
ΔGtransfer -43.3 kcal/mol
ΔGfold -21.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 245-270 (245-274)
Pathways

Allograft rejection (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Systemic lupus erythematosus (KEGG)

Toll-like receptor signaling pathway (KEGG)

Transcriptional misregulation in cancer (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 1ncn (26-134), 1i85 (A/B=26-134)
OPM none
Complexes

CD86:CTLA4_HUMAN

Interactions

CD28, Complex: CD28:CD86, PubMed

CD80, Complex: CD80:CD86, PubMed

CTLA4, Complex: CD86:CTLA4, PDBID: 1i85

ECE2, Complex: CD86:ECE2, PubMed

Domains

AA: 24-132, PDBID: 1I85, Subunit B, Seq Identity:100%, Immunoglobulin V-set domain

AA: 138-236, PDBID: 2ENS, Subunit A, Seq Identity:15%, Immunoglobulin domain

UniProt annotation for CD86_HUMAN » T-lymphocyte activation antigen CD86
FUNCTION: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T- cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.

SUBUNIT: Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein (Probable). Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

TISSUE SPECIFICITY: Expressed by activated B-lymphocytes and monocytes.

UniProt features for CD86_HUMAN » T-lymphocyte activation antigen CD86
SIGNAL 1 23 Potential.
CHAIN 24 329 T-lymphocyte activation antigen CD86.
DOMAIN 33 131 Ig-like V-type.
DOMAIN 150 225 Ig-like C2-type.
DISULFID 40 110
DISULFID 157 218 Potential.
Amino Acid Sequence for CD86_HUMAN » T-lymphocyte activation antigen CD86
MDPQCTMGLS NILFVMAFLL SGAAPLKIQA YFNETADLPC QFANSQNQSL SELVVFWQDQ ENLVLNEVYL GKEKFDSVHS KYMGRTSFDS DSWTLRLHNL QIKDKGLYQC IIHHKKPTGM IRIHQMNSEL SVLANFSQPE IVPISNITEN VYINLTCSSI HGYPEPKKMS VLLRTKNSTI EYDGIMQKSQ DNVTELYDVS ISLSVSFPDV TSNMTIFCIL ETDKTRLLSS PFSIELEDPQ PPPDHIPWIT AVLPTVIICV MVFCLILWKW KKKKRPRNSY KCGTNTMERE ESEQTKKREK IHIPERSDEA QRVFKSSKTS SCDKSDTCF