CD80_HUMAN » T-lymphocyte activation antigen CD80

CD80_HUMAN » T-lymphocyte activation antigen CD80
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Topology in Plasma membrane
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cytoplasmic side
CD80_HUMAN » T-lymphocyte activation antigen CD80 » Activation B7-1 antigen;BB1;CTLA-4 counter-receptor B7.1;B7;
Hydrophobic Thickness 34.0 ± 3.2 Å
Tilt Angle 15 ± 8°
ΔGtransfer -17.0 kcal/mol
ΔGfold -6.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 244-267 (243-268)
Pathways

Allograft rejection (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Systemic lupus erythematosus (KEGG)

Toll-like receptor signaling pathway (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 1dr9 (35-233), 1i8l (A/B=35-242)
OPM none
Complexes

CD80:CTLA4_HUMAN

Interactions

CD28, Complex: CD28:CD80, PubMed

CD86, Complex: CD80:CD86, PubMed

CTLA4, Complex: CD80:CTLA4, PDBID: 1i8l

PD1L1, Complex: PD1L1:CD80

TNR16, Complex: CD80:TNR16

Domains

AA: 36-135, PDBID: 1DR9, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 141-227, PDBID: 1DR9, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

UniProt annotation for CD80_HUMAN » T-lymphocyte activation antigen CD80
FUNCTION: Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation.

SUBUNIT: Homodimer; CD80 dimers on the antigen presenting cells (APCs) bridge CTLA4/CD152 dimers on T-cells in a periodic zipper- like arrangement. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses.

TISSUE SPECIFICITY: Expressed on activated B-cells, macrophages and dendritic cells.

UniProt features for CD80_HUMAN » T-lymphocyte activation antigen CD80
SIGNAL 1 34
CHAIN 35 288 T-lymphocyte activation antigen CD80.
DOMAIN 35 135 Ig-like V-type.
DOMAIN 145 230 Ig-like C2-type.
DISULFID 50 116
DISULFID 162 216
Amino Acid Sequence for CD80_HUMAN » T-lymphocyte activation antigen CD80
MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV