CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain

CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain
Magnify CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain » B-cell-specific glycoprotein B29;Ig-beta;Immunoglobulin-associated B29 protein;
Hydrophobic Thickness 28.0 ± 1.6 Å
Tilt Angle 0 ± 1°
ΔGtransfer -46.1 kcal/mol
ΔGfold -20.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 160-185 (160-188)
Pathways

B cell receptor signaling pathway (KEGG)

Immune System (Reactome)

PDB 3kg5 (A/B=26-159)
OPM none
Complexes

CD79B:CD79B_MOUSE

Interactions

BTLA, Complex: CD79B:BTLA:CD79A:CD19

CD19, Complex: CD19:CD79B, PubMed

CD3E, Complex: CD79B:CD3E, PubMed

CD5, Complex: CD5:CD79B, PubMed

CD79A, Complex: CD79A:CD79B, PubMed

CD79B, Complex: Homodimer of B-cell antigen receptor, PDBID: 3KHO

PTPRC, Complex: CD79B:PTPRC, PubMed

Domains

AA: 48-143, PDBID: 3KG5, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

UniProt annotation for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain
FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation.

SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity).

TISSUE SPECIFICITY: B-cells.

DISEASE: Agammaglobulinemia 6, autosomal recessive (AGM6) OMIM: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. by mutations affecting the gene represented in this entry.

UniProt features for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain
SIGNAL 1 28
CHAIN 29 229 B-cell antigen receptor complex- associated protein beta chain.
DOMAIN 38 138 Ig-like V-type.
DOMAIN 185 213 ITAM.
DISULFID 43 126
DISULFID 65 122
DISULFID 136 136 Interchain (with C-119 in alpha chain).
Amino Acid Sequence for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain
MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE