|CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain » B-cell-specific glycoprotein B29;Ig-beta;Immunoglobulin-associated B29 protein;|
|Hydrophobic Thickness||28.0 ± 1.6 Å|
|Tilt Angle||0 ± 1°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC|
|TM Segments||160-185 (160-188)|
Immune System (Reactome)
BTLA, Complex: CD79B:BTLA:CD79A:CD19
|UniProt annotation for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain|
|FUNCTION: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. SUBUNIT: Heterodimer of alpha and beta chains; disulfide-linked. Part of the B-cell antigen receptor complex where the alpha/beta chain heterodimer is non-covalently associated with an antigen- specific membrane-bound surface immunoglobulin of two heavy chains and two light chains. Interacts with LYN (By similarity). TISSUE SPECIFICITY: B-cells. DISEASE: Agammaglobulinemia 6, autosomal recessive (AGM6) OMIM: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. by mutations affecting the gene represented in this entry.|
|UniProt features for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain|
SIGNAL 1 28 |
CHAIN 29 229 B-cell antigen receptor complex- associated protein beta chain.
DOMAIN 38 138 Ig-like V-type.
DOMAIN 185 213 ITAM.
DISULFID 43 126
DISULFID 65 122
DISULFID 136 136 Interchain (with C-119 in alpha chain).
|Amino Acid Sequence for CD79B_HUMAN » B-cell antigen receptor complex-associated protein beta chain|
|MARLALSPVP SHWMVALLLL LSAEPVPAAR SEDRYRNPKG SACSRIWQSP RFIARKRGFT VKMHCYMNSA SGNVSWLWKQ EMDENPQQLK LEKGRMEESQ NESLATLTIQ GIRFEDNGIY FCQQKCNNTS EVYQGCGTEL RVMGFSTLAQ LKQRNTLKDG IIMIQTLLII LFIIVPIFLL LDKDDSKAGM EEDHTYEGLD IDQTATYEDI VTLRTGEVKW SVGEHPGQE|