CD72_HUMAN » B-cell differentiation antigen CD72

CD72_HUMAN » B-cell differentiation antigen CD72
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD72_HUMAN » B-cell differentiation antigen CD72 » Lyb-2;
Hydrophobic Thickness 38.4 ± 1.2 Å
Tilt Angle 0 ± 3°
ΔGtransfer -45.7 kcal/mol
ΔGfold -16.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology In
TM Segments 91-116 (91-123)
Pathways

B cell receptor signaling pathway (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

CD5, Complex: CD72:CD5, PubMed

SEM4D, Complex: CD72:SEM4D, PubMed

Domains

AA: 250-352, PDBID: 3FF8, Subunit C, Seq Identity:27%, Lectin C-type domain

UniProt annotation for CD72_HUMAN » B-cell differentiation antigen CD72
FUNCTION: Plays a role in B-cell proliferation and differentiation.

SUBUNIT: Homodimer; disulfide-linked. Associates with CD5. Interacts (tyrosine phosphorylated) with PTPN6/SHP-1 (By similarity).

TISSUE SPECIFICITY: Pre-B-cells and B-cells but not terminally differentiated plasma cells.

UniProt features for CD72_HUMAN » B-cell differentiation antigen CD72
CHAIN 1 359 B-cell differentiation antigen CD72.
DOMAIN 232 352 C-type lectin.
DISULFID 233 244 By similarity.
DISULFID 261 350 By similarity.
DISULFID 325 342 By similarity.
Amino Acid Sequence for CD72_HUMAN » B-cell differentiation antigen CD72
MAEAITYADL RFVKAPLKKS ISSRLGQDPG ADDDGEITYE NVQVPAVLGV PSSLASSVLG DKAAVKSEQP TASWRAVTSP AVGRILPCRT TCLRYLLLGL LLTCLLLGVT AICLGVRYLQ VSQQLQQTNR VLEVTNSSLR QQLRLKITQL GQSAEDLQGS RRELAQSQEA LQVEQRAHQA AEGQLQACQA DRQKTKETLQ SEEQQRRALE QKLSNMENRL KPFFTCGSAD TCCPSGWIMH QKSCFYISLT SKNWQESQKQ CETLSSKLAT FSEIYPQSHS YYFLNSLLPN GGSGNSYWTG LSSNKDWKLT DDTQRTRTYA QSSKCNKVHK TWSWWTLESE SCRSSLPYIC EMTAFRFPD