CD70_HUMAN » CD70 antigen

CD70_HUMAN » CD70 antigen
Magnify CD70_HUMAN » CD70 antigenEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD70_HUMAN » CD70 antigen » CD27 ligand;CD27-L; Tumor necrosis factor ligand superfamily member 7;
Hydrophobic Thickness 32.8 ± 5.4 Å
Tilt Angle 42 ± 10°
ΔGtransfer -23.3 kcal/mol
ΔGfold -11.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 14-39 (14-45)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

CD27, Complex: CD70:CD27, PubMed

Domains

AA: 73-191, PDBID: 1ALY, Subunit A, Seq Identity:22%, TNF(Tumour Necrosis Factor) family

UniProt annotation for CD70_HUMAN » CD70 antigen
FUNCTION: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells.

SUBUNIT: Homotrimer.

UniProt features for CD70_HUMAN » CD70 antigen
CHAIN 1 193 CD70 antigen.
DISULFID 133 151 Potential.
Amino Acid Sequence for CD70_HUMAN » CD70 antigen
MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN TDETFFGVQW VRP