CD6_HUMAN » T-cell differentiation antigen CD6

CD6_HUMAN » T-cell differentiation antigen CD6
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD6_HUMAN » T-cell differentiation antigen CD6 » T12;TP120;
Hydrophobic Thickness 36.8 ± 4.4 Å
Tilt Angle 36 ± 0°
ΔGtransfer -30.0 kcal/mol
ΔGfold -26.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 395-424 (394-427)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

CD166, Complex: CD6:CD166, PubMed

CD5, Complex: CD6:CD5, PubMed

NF2L1, Complex: CD6:NF2L1, PubMed

Domains

AA: 48-156, PDBID: 5A2E, Subunit A, Seq Identity:100%, Scavenger receptor cysteine-rich domain

AA: 164-260, PDBID: 5A2E, Subunit A, Seq Identity:100%, Scavenger receptor cysteine-rich domain

AA: 268-361, PDBID: 5A2E, Subunit A, Seq Identity:100%, Scavenger receptor cysteine-rich domain

UniProt annotation for CD6_HUMAN » T-cell differentiation antigen CD6
FUNCTION: Involved in cell adhesion. Binds to CD166.

TISSUE SPECIFICITY: Expressed by thymocytes, mature T-cells, a subset of B-cells known as B-1 cells, and by some cells in the brain.

UniProt features for CD6_HUMAN » T-cell differentiation antigen CD6
SIGNAL 1 17 Potential.
CHAIN 18 668 T-cell differentiation antigen CD6.
DOMAIN 45 156 SRCR 1.
DOMAIN 161 260 SRCR 2.
DOMAIN 265 361 SRCR 3.
DISULFID 70 144 By similarity.
DISULFID 83 155 By similarity.
DISULFID 129 137 By similarity.
DISULFID 186 249 By similarity.
DISULFID 199 259 By similarity.
DISULFID 230 240 By similarity.
DISULFID 290 350 By similarity.
DISULFID 303 360 By similarity.
DISULFID 330 340 By similarity.
Amino Acid Sequence for CD6_HUMAN » T-cell differentiation antigen CD6
MWLFFGITGL LTAALSGHPS PAPPDQLNTS SAESELWEPG ERLPVRLTNG SSSCSGTVEV RLEASWEPAC GALWDSRAAE AVCRALGCGG AEAASQLAPP TPELPPPPAA GNTSVAANAT LAGAPALLCS GAEWRLCEVV EHACRSDGRR ARVTCAENRA LRLVDGGGAC AGRVEMLEHG EWGSVCDDTW DLEDAHVVCR QLGCGWAVQA LPGLHFTPGR GPIHRDQVNC SGAEAYLWDC PGLPGQHYCG HKEDAGVVCS EHQSWRLTGG ADRCEGQVEV HFRGVWNTVC DSEWYPSEAK VLCQSLGCGT AVERPKGLPH SLSGRMYYSC NGEELTLSNC SWRFNNSNLC SQSLAARVLC SASRSLHNLS TPEVPASVQT VTIESSVTVK IENKESRELM LLIPSIVLGI LLLGSLIFIA FILLRIKGKY ALPVMVNHQH LPTTIPAGSN SYQPVPITIP KEVFMLPIQV QAPPPEDSDS GSDSDYEHYD FSAQPPVALT TFYNSQRHRV TDEEVQQSRF QMPPLEEGLE ELHASHIPTA NPGHCITDPP SLGPQYHPRS NSESSTSSGE DYCNSPKSKL PPWNPQVFSS ERSSFLEQPP NLELAGTQPA FSAGPPADDS SSTSSGEWYQ NFQPPPQPPS EEQFGCPGSP SPQPDSTDND DYDDISAA