CD69_HUMAN » Early activation antigen CD69

CD69_HUMAN » Early activation antigen CD69
Magnify CD69_HUMAN » Early activation antigen CD69Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD69_HUMAN » Early activation antigen CD69 » Activation inducer molecule;AIM; BL-AC/P26;C-type lectin domain family 2 member C;EA1;Early T-cell activation antigen p60;GP32/28;Leukocyte surface antigen Leu-23;MLR-3;
Hydrophobic Thickness 34.8 ± 5.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -32.6 kcal/mol
ΔGfold -18.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 41-65 (38-66)
Pathways none
PDB 3hup (A/B=70-199), 1e8i (A/B=82-199), 3cck (A/B=82-199), 1fm5 (A=1-199), 1e87 (A=82-199)
OPM none
Complexes

CD69:CD69_HUMAN

Interactions

CD69, Complex: Homodimer of early activation antigen cd69, PDBID: 3HUP

TM190, Complex: TM190:CD69

Domains

AA: 102-196, PDBID: 1E87, Subunit A, Seq Identity:100%, Lectin C-type domain

UniProt annotation for CD69_HUMAN » Early activation antigen CD69
FUNCTION: Involved in lymphocyte proliferation and functions as a signal transmitting receptor in lymphocytes, natural killer (NK) cells, and platelets.

SUBUNIT: Homodimer; disulfide-linked.

TISSUE SPECIFICITY: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.

DEVELOPMENTAL STAGE: Earliest inducible cell surface glycoprotein acquired during lymphoid activation.

INDUCTION: By antigens, mitogens or activators of PKC on the surface of T and B-lymphocytes. By interaction of IL-2 with the p75 IL-2R on the surface of NK cells.

UniProt features for CD69_HUMAN » Early activation antigen CD69
CHAIN 1 199 Early activation antigen CD69.
DOMAIN 92 195 C-type lectin.
DISULFID 68 68 Interchain (Probable).
DISULFID 85 96
DISULFID 113 194
DISULFID 173 186
Amino Acid Sequence for CD69_HUMAN » Early activation antigen CD69
MSSENCFVAE NSSLHPESGQ ENDATSPHFS TRHEGSFQVP VLCAVMNVVF ITILIIALIA LSVGQYNCPG QYTFSMPSDS HVSSCSEDWV GYQRKCYFIS TVKRSWTSAQ NACSEHGATL AVIDSEKDMN FLKRYAGREE HWVGLKKEPG HPWKWSNGKE FNNWFNVTGS DKCVFLKNTE VSSMECEKNL YWICNKPYK