CD68_HUMAN » Macrosialin

CD68_HUMAN » Macrosialin
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Topology in Lysosomal membrane
Topologylysosome lumenal side
cytoplasmic side
CD68_HUMAN » Macrosialin » Gp110;
Hydrophobic Thickness 40.0 ± 3.2 Å
Tilt Angle 6 ± 5°
ΔGtransfer -33.5 kcal/mol
ΔGfold -27.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 317-344 (315-347)
Pathways

Lysosome (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 37-354, PDBID: 4AKM, Subunit B, Seq Identity:22%, Lysosome-associated membrane glycoprotein (Lamp)

UniProt annotation for CD68_HUMAN » Macrosialin
FUNCTION: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells.

TISSUE SPECIFICITY: Highly expressed by blood monocytes and tissue macrophages. Also expressed in lymphocytes, fibroblasts and endothelial cells. Expressed in many tumor cell lines which could allow them to attach to selectins on vascular endothelium, facilitating their dissemination to secondary sites.

UniProt features for CD68_HUMAN » Macrosialin
SIGNAL 1 21 Potential.
CHAIN 22 354 Macrosialin.
REPEAT 70 99 1.
REPEAT 100 129 2.
REGION 23 140 Mucin-like.
REGION 70 129 2 X 30 AA tandem repeats.
DISULFID 169 207 By similarity.
DISULFID 277 314 By similarity.
Amino Acid Sequence for CD68_HUMAN » Macrosialin
MRLAVLFSGA LLGLLAAQGT GNDCPHKKSA TLLPSFTVTP TVTESTGTTS HRTTKSHKTT THRTTTTGTT SHGPTTATHN PTTTSHGNVT VHPTSNSTAT SQGPSTATHS PATTSHGNAT VHPTSNSTAT SPGFTSSAHP EPPPPSPSPS PTSKETIGDY TWTNGSQPCV HLQAQIQIRV MYTTQGGGEA WGISVLNPNK TKVQGSCEGA HPHLLLSFPY GHLSFGFMQD LQQKVVYLSY MAVEYNVSFP HAAQWTFSAQ NASLRDLQAP LGQSFSCSNS SIILSPAVHL DLLSLRLQAA QLPHTGVFGQ SFSCPSDRSI LLPLIIGLIL LGLLALVLIA FCIIRRRPSA YQAL