CD5_HUMAN » T-cell surface glycoprotein CD5

CD5_HUMAN » T-cell surface glycoprotein CD5
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD5_HUMAN » T-cell surface glycoprotein CD5 » Lymphocyte antigen T1/Leu-1;
Hydrophobic Thickness 35.2 ± 2.8 Å
Tilt Angle 43 ± 0°
ΔGtransfer -29.9 kcal/mol
ΔGfold -24.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 375-405 (375-412)
Pathways

Hematopoietic cell lineage (KEGG)

oleate biosynthesis II (animals) (BioCyc)

PDB 2jop (25-134), 2jp0 (25-134), 2ja4 (270-369), 2ott (276-368)
OPM none
Complexes none
Interactions

CD27, Complex: CD5:CD27, PubMed

CD2, Complex: CD2:CD5, PubMed

CD3Z, Complex: CD5:CD3Z, PubMed

CD4, Complex: CD5:CD4, PubMed

CD6, Complex: CD6:CD5, PubMed

CD72, Complex: CD72:CD5, PubMed

CD79A, Complex: CD79A:CD5, PubMed

CD79B, Complex: CD5:CD79B, PubMed

Domains

AA: 38-133, PDBID: 2JOP, Subunit A, Seq Identity:100%, Scavenger receptor cysteine-rich domain

UniProt annotation for CD5_HUMAN » T-cell surface glycoprotein CD5
FUNCTION: May act as a receptor in regulating T-cell proliferation.

SUBUNIT: Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1 (By similarity).

UniProt features for CD5_HUMAN » T-cell surface glycoprotein CD5
SIGNAL 1 24
CHAIN 25 495 T-cell surface glycoprotein CD5.
DOMAIN 35 133 SRCR 1.
DOMAIN 159 268 SRCR 2.
DOMAIN 276 368 SRCR 3.
DISULFID 44 86
DISULFID 60 125
DISULFID 81 132
DISULFID 107 117
DISULFID 201 267 By similarity.
DISULFID 244 250 By similarity.
DISULFID 285 321
DISULFID 301 360
DISULFID 316 367
DISULFID 342 350
Amino Acid Sequence for CD5_HUMAN » T-cell surface glycoprotein CD5
MPMGSLQPLA TLYLLGMLVA SCLGRLSWYD PDFQARLTRS NSKCQGQLEV YLKDGWHMVC SQSWGRSSKQ WEDPSQASKV CQRLNCGVPL SLGPFLVTYT PQSSIICYGQ LGSFSNCSHS RNDMCHSLGL TCLEPQKTTP PTTRPPPTTT PEPTAPPRLQ LVAQSGGQHC AGVVEFYSGS LGGTISYEAQ DKTQDLENFL CNNLQCGSFL KHLPETEAGR AQDPGEPREH QPLPIQWKIQ NSSCTSLEHC FRKIKPQKSG RVLALLCSGF QPKVQSRLVG GSSICEGTVE VRQGAQWAAL CDSSSARSSL RWEEVCREQQ CGSVNSYRVL DAGDPTSRGL FCPHQKLSQC HELWERNSYC KKVFVTCQDP NPAGLAAGTV ASIILALVLL VVLLVVCGPL AYKKLVKKFR QKKQRQWIGP TGMNQNMSFH RNHTATVRSH AENPTASHVD NEYSQPPRNS RLSAYPALEG VLHRSSMQPD NSSDSDYDLH GAQRL