CD4_HUMAN » T-cell surface glycoprotein CD4

CD4_HUMAN » T-cell surface glycoprotein CD4
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD4_HUMAN » T-cell surface glycoprotein CD4 » T-cell surface antigen T4/Leu-3;
Hydrophobic Thickness 34.0 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -50.9 kcal/mol
ΔGfold -19.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 396-421 (396-430)
Pathways

Antigen processing and presentation (KEGG)

Cell adhesion molecules (KEGG)

D-myo-inositol (1,4,5)-trisphosphate biosynthesis (BioCyc)

D-myo-inositol-5-phosphate metabolism (BioCyc)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

phospholipases (BioCyc)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 1cdj (26-203), 1cdu (26-203), 1cdy (26-203), 1wiq (26-388), 1wio (26-388), 1wip (26-388), 2klu (397-458), 1wbr (428-444), 1cdi (A=26-203), 1cdh (A=26-203), 3o2d (A=26-207), 3cd4 (A=26-207), 1q68 (A=421-458), 4r2g (B/F/H/L=26-208), 2qad (B/F=26-206), 4r4h (B=26-203), 4rqs (B=26-208), 2ny6 (B=26-208), 2ny4 (B=26-208), 2ny3 (B=26-208), 2ny2 (B=26-208), 2ny1 (B=26-208), 2nxz (B=26-208), 2nxy (B=26-208), 2ny0 (B=26-208), 3jwd (C/D=26-208), 4q6i (C/I/J/K=1-208), 1gc1 (C=26-206), 2b4c (C=26-206), 3lqa (C=26-207), 4p9h (C=26-207), 1rzj (C=26-208), 3jwo (C=26-208), 1rzk (C=26-208), 4h8w (C=26-208), 2ny5 (C=26-208), 1g9n (C=26-208), 1g9m (C=26-208), 3b71 (D/E/F=428-450), 1jl4 (D=26-203), 3t0e (E=26-388), 4jm2 (F=26-208), 3s4s (G/H=26-203), 3s5l (G/H=26-203), 2jkr (P/Q=431-441), 2jkt (P/Q=435-441)
OPM 2klu
Complexes

DRA:2B11:CD4:HEMA_HUMAN

2B14:TRBC2:DRA:TCA:CD4_HUMAN

Interactions

2B11, Complex: DRA:2B11:CD4:HEMA, PDBID: 3S4S

4F2, Complex: 4F2:CD4, PubMed

CD28, Complex: CD4:CD28, PubMed

CD2, Complex: CD4:CD2, PubMed

CD38, Complex: CD38:CD4, PubMed

CD44, Complex: CD4:CD44, PubMed

CD4, Complex: Homodimer of T-cell surface glycoprotein CD4, PDBID: 3JWD

CD5, Complex: CD5:CD4, PubMed

DPA1, Complex: DPA1:CD4, PubMed

DPP4, Complex: CD4:DPP4, PubMed

DQA2, Complex: DQA2:CD4, PubMed

DQB1, Complex: CD4:DQB1, PubMed

FCG3A, Complex: FCG3A:CD4, PubMed

HRD3, Complex: CD4:HRD3, PubMed

IL2RA, Complex: IL2RA:CD4, PubMed

LAT, Complex: LAT:CD4, PubMed

LYAM1, Complex: CD4:LYAM1, PubMed

NEP, Complex: CD4:NEP, PubMed

PTPRC, Complex: CD4:PTPRC, PubMed

TCA, Complex: 2B14:TRBC2:DRA:TCA:CD4, PDBID: 3T0E

TFR1, Complex: CD4:TFR1, PubMed

TR10A, Complex: TR10A:CD4, PubMed

Domains

AA: 24-123, PDBID: 1CDH, Subunit A, Seq Identity:100%, Immunoglobulin domain

AA: 125-203, PDBID: 1CDH, Subunit A, Seq Identity:100%, Immunoglobulin C2-set domain

AA: 206-316, PDBID: 1WIO, Subunit A, Seq Identity:100%, CD4, extracellular

AA: 317-390, PDBID: 1WIO, Subunit A, Seq Identity:100%, Immunoglobulin C2-set domain

AA: 426-453, PDBID: 1Q68, Subunit A, Seq Identity:100%, T cell CD4 receptor C terminal region

UniProt annotation for CD4_HUMAN » T-cell surface glycoprotein CD4
FUNCTION: Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.

SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu. Interacts with Human Herpes virus 7 capsid proteins. Interacts with PTK2/FAK1; this interaction requires the presence of HIV-1 gp120.

MISCELLANEOUS: Primary receptor for HIV-1.

UniProt features for CD4_HUMAN » T-cell surface glycoprotein CD4
SIGNAL 1 25
CHAIN 26 458 T-cell surface glycoprotein CD4.
DOMAIN 26 125 Ig-like V-type.
DOMAIN 126 203 Ig-like C2-type 1.
DOMAIN 204 317 Ig-like C2-type 2.
DOMAIN 318 374 Ig-like C2-type 3.
REGION 427 455 HIV-1 Vpu-susceptibility domain.
DISULFID 41 109
DISULFID 155 184
DISULFID 328 370
Amino Acid Sequence for CD4_HUMAN » T-cell surface glycoprotein CD4
MNRGVPFRHL LLVLQLALLP AATQGKKVVL GKKGDTVELT CTASQKKSIQ FHWKNSNQIK ILGNQGSFLT KGPSKLNDRA DSRRSLWDQG NFPLIIKNLK IEDSDTYICE VEDQKEEVQL LVFGLTANSD THLLQGQSLT LTLESPPGSS PSVQCRSPRG KNIQGGKTLS VSQLELQDSG TWTCTVLQNQ KKVEFKIDIV VLAFQKASSI VYKKEGEQVE FSFPLAFTVE KLTGSGELWW QAERASSSKS WITFDLKNKE VSVKRVTQDP KLQMGKKLPL HLTLPQALPQ YAGSGNLTLA LEAKTGKLHQ EVNLVVMRAT QLQKNLTCEV WGPTSPKLML SLKLENKEAK VSKREKAVWV LNPEAGMWQC LLSDSGQVLL ESNIKVLPTW STPVQPMALI VLGGVAGLLL FIGLGIFFCV RCRHRRRQAE RMSQIKRLLS EKKTCQCPHR FQKTCSPI