CD44_HUMAN » CD44 antigen

CD44_HUMAN » CD44 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD44_HUMAN » CD44 antigen » CDw44;Epican;Extracellular matrix receptor III;ECMR-III; GP90 lymphocyte homing/adhesion receptor;HUTCH-I;Heparan sulfate proteoglycan;Hermes antigen;Hyaluronate receptor;Phagocytic glycoprotein 1;PGP-1; Phagocytic glycoprotein I;PGP-I;
Hydrophobic Thickness 28.4 ± 1.8 Å
Tilt Angle 3 ± 2°
ΔGtransfer -31.3 kcal/mol
ΔGfold -24.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 648-672 (648-675)
Pathways

ECM-receptor interaction (KEGG)

Epstein-Barr virus infection (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

Proteoglycans in cancer (KEGG)

Shigellosis (KEGG)

PDB 4pz4 (18-171), 1poz (20-178), 1uuh (20-178), 2i83 (21-178), 4pz3 (A/B=18-170)
OPM none
Complexes

CD44:CD44_HUMAN

Interactions

4F2, Complex: 4F2:CD44, PubMed

BMPR2, Complex: CD44:BMPR2, PubMed

CD44, Complex: Homodimer of CD44 antigen, PDBID: 4PZ3

CD4, Complex: CD4:CD44, PubMed

EGFR, Complex: CD44:EGFR, PubMed

ERBB2, Complex: CD44:ARP3:ERBB2:ARP2:WASL, PubMed

ERBB4, Complex: ERBB4:CD44, PubMed

HBEGF, Complex: HBEGF:CD44, PubMed

HG2A, Complex: HG2A:CD44, PubMed

ICAM2, Complex: CD44:ICAM2:RADI:LEUK, PubMed

ITA4, Complex: ITA4:CD44, PubMed

ITB1, Complex: CD44:ITB1, PubMed

LYAM2, Complex: LYAM2:CD44, PubMed

MADCA, Complex: CD44:MADCA, PubMed

MET, Complex: CD44:MET, PubMed

PTPRC, Complex: PTPRC:CD44, PubMed

TGFR1, Complex: CD44:TGFR1, PubMed

TGFR2, Complex: CD44:TGFR2, PubMed

TLR2, Complex: TLR2:CD44, PubMed

Domains

AA: 32-119, PDBID: 1POZ, Subunit A, Seq Identity:100%, Extracellular link domain

UniProt annotation for CD44_HUMAN » CD44 antigen
FUNCTION: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.

SUBUNIT: Interacts with PKN2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N- terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119.

TISSUE SPECIFICITY: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

DOMAIN: The lectin-like LINK domain is responsible for hyaluronan binding.

UniProt features for CD44_HUMAN » CD44 antigen
SIGNAL 1 20 By similarity.
CHAIN 21 742 CD44 antigen.
DOMAIN 32 120 Link.
REGION 224 649 Stem.
DISULFID 28 129 By similarity.
DISULFID 53 118 By similarity.
DISULFID 77 97 By similarity.
Amino Acid Sequence for CD44_HUMAN » CD44 antigen
MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK EQWFGNRWHE GYRQTPREDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW TDFFNPISHP MGRGHQAGRR MDMDSSHSTT LQPTANPNTG LVEDLDRTGP LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV