|CD44_HUMAN » CD44 antigen » CDw44;Epican;Extracellular matrix receptor III;ECMR-III; GP90 lymphocyte homing/adhesion receptor;HUTCH-I;Heparan sulfate proteoglycan;Hermes antigen;Hyaluronate receptor;Phagocytic glycoprotein 1;PGP-1; Phagocytic glycoprotein I;PGP-I;|
|Hydrophobic Thickness||28.4 ± 1.8 Å|
|Tilt Angle||3 ± 2°|
|Links||UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB|
|TM Segments||648-672 (648-675)|
ECM-receptor interaction (KEGG)
Epstein-Barr virus infection (KEGG)
Hematopoietic cell lineage (KEGG)
Immune System (Reactome)
Proteoglycans in cancer (KEGG)
|PDB||4pz4 (18-171), 1poz (20-178), 1uuh (20-178), 2i83 (21-178), 4pz3 (A/B=18-170)|
|UniProt annotation for CD44_HUMAN » CD44 antigen|
|FUNCTION: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. SUBUNIT: Interacts with PKN2. Interacts with TIAM1 and TIAM2 (By similarity). Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N- terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment. Interacts with UNC119. TISSUE SPECIFICITY: Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells. DOMAIN: The lectin-like LINK domain is responsible for hyaluronan binding.|
|UniProt features for CD44_HUMAN » CD44 antigen|
SIGNAL 1 20 By similarity. |
CHAIN 21 742 CD44 antigen.
DOMAIN 32 120 Link.
REGION 224 649 Stem.
DISULFID 28 129 By similarity.
DISULFID 53 118 By similarity.
DISULFID 77 97 By similarity.
|Amino Acid Sequence for CD44_HUMAN » CD44 antigen|
|MDKFWWHAAW GLCLVPLSLA QIDLNITCRF AGVFHVEKNG RYSISRTEAA DLCKAFNSTL PTMAQMEKAL SIGFETCRYG FIEGHVVIPR IHPNSICAAN NTGVYILTSN TSQYDTYCFN ASAPPEEDCT SVTDLPNAFD GPITITIVNR DGTRYVQKGE YRTNPEDIYP SNPTDDDVSS GSSSERSSTS GGYIFYTFST VHPIPDEDSP WITDSTDRIP ATTLMSTSAT ATETATKRQE TWDWFSWLFL PSESKNHLHT TTQMAGTSSN TISAGWEPNE ENEDERDRHL SFSGSGIDDD EDFISSTIST TPRAFDHTKQ NQDWTQWNPS HSNPEVLLQT TTRMTDVDRN GTTAYEGNWN PEAHPPLIHH EHHEEEETPH STSTIQATPS STTEETATQK EQWFGNRWHE GYRQTPREDS HSTTGTAAAS AHTSHPMQGR TTPSPEDSSW TDFFNPISHP MGRGHQAGRR MDMDSSHSTT LQPTANPNTG LVEDLDRTGP LSMTTQQSNS QSFSTSHEGL EEDKDHPTTS TLTSSNRNDV TGGRRDPNHS EGSTTLLEGY TSHYPHTKES RTFIPVTSAK TGSFGVTAVT VGDSNSNVNR SLSGDQDTFH PSGGSHTTHG SESDGHSHGS QEGGANTTSG PIRTPQIPEW LIILASLLAL ALILAVCIAV NSRRRCGQKK KLVINSGNGA VEDRKPSGLN GEASKSQEMV HLVNKESSET PDQFMTADET RNLQNVDMKI GV|