CD40L_HUMAN » CD40 ligand

CD40L_HUMAN » CD40 ligand
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD40L_HUMAN » CD40 ligand » CD40-L; T-cell antigen Gp39;TNF-related activation protein;TRAP; Tumor necrosis factor ligand superfamily member 5;
Hydrophobic Thickness 37.2 ± 4.6 Å
Tilt Angle 38 ± 3°
ΔGtransfer -23.8 kcal/mol
ΔGfold -19.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 18-47 (18-50)
Pathways

Allograft rejection (KEGG)

Asthma (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Cytokine-cytokine receptor interaction (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Malaria (KEGG)

NF-kappa B signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

Systemic lupus erythematosus (KEGG)

T cell receptor signaling pathway (KEGG)

Toxoplasmosis (KEGG)

Viral myocarditis (KEGG)

PDB 3qd6 (A/B...=116-261), 1i9r (A/B/C=116-261), 3lkj (A/B/C=121-261), 1aly (A=116-261)
OPM none
Complexes

TNR5:CD40L_HUMAN

CD40L:CD40L_HUMAN

Interactions

CD40L, Complex: Homotrimer of cytokine CD40L, PDBID: 3LKJ

RN128, Complex: RN128:CD40L, PubMed

TNR5, Complex: CD40L:TNR5, PDBID: 3QD6, PubMed

Domains

AA: 138-261, PDBID: 1ALY, Subunit A, Seq Identity:100%, TNF(Tumour Necrosis Factor) family

UniProt annotation for CD40L_HUMAN » CD40 ligand
FUNCTION: Mediates B-cell proliferation in the absence of co- stimulus as well as IgE production in the presence of IL-4. Involved in immunoglobulin class switching.

FUNCTION: Release of soluble CD40L from platelets is partially regulated by GP IIb/IIIa, actin polymerization, and an matrix metalloproteinases (MMP) inhibitor-sensitive pathway.

SUBUNIT: Homotrimer.

TISSUE SPECIFICITY: Specifically expressed on activated CD4+ T- lymphocytes.

DISEASE: X-linked immunodeficiency with hyper-IgM 1 (HIGM1) OMIM: Immunoglobulin isotype switch defect characterized by elevated concentrations of serum IgM and decreased amounts of all other isotypes. Affected males present at an early age (usually within the first year of life) recurrent bacterial and opportunistic infections, including Pneumocystis carinii pneumonia and intractable diarrhea due to cryptosporidium infection. Despite substitution treatment with intravenous immunoglobulin, the overall prognosis is rather poor, with a death rate of about 10% before adolescence. mutations affecting the gene represented in this entry.

UniProt features for CD40L_HUMAN » CD40 ligand
CHAIN 1 261 CD40 ligand, membrane form.
CHAIN 113 261 CD40 ligand, soluble form.
SITE 112 113 Cleavage.
DISULFID 178 218 Potential.
Amino Acid Sequence for CD40L_HUMAN » CD40 ligand
MIETYNQTSP RSAATGLPIS MKIFMYLLTV FLITQMIGSA LFAVYLHRRL DKIEDERNLH EDFVFMKTIQ RCNTGERSLS LLNCEEIKSQ FEGFVKDIML NKEETKKENS FEMQKGDQNP QIAAHVISEA SSKTTSVLQW AEKGYYTMSN NLVTLENGKQ LTVKRQGLYY IYAQVTFCSN REASSQAPFI ASLCLKSPGR FERILLRAAN THSSAKPCGQ QSIHLGGVFE LQPGASVFVN VTDPSQVSHG TGFTSFGLLK L