CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain

CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain
Magnify CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chainEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain » T-cell receptor T3 zeta chain;
Hydrophobic Thickness 32.0 ± 2.0 Å
Tilt Angle 1 ± 1°
ΔGtransfer -38.7 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 31-55 (29-58)
Pathways

Chagas disease (KEGG)

Immune System (Reactome)

Natural killer cell mediated cytotoxicity (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 2hac (A/B=28-60), 3ik5 (B/D=63-80), 1tce (B=137-150), 3ioz (B=51-93), 2oq1 (B=69-87), 1ygr (C/D=80-85)
OPM 2hac, 3ik5
Complexes

CD3Z:CD3Z_HUMAN

Interactions

ACE, Complex: CD3Z:ACE, PubMed

CALX, Complex: CD3Z:CALX, PubMed

CBPD, Complex: CD3Z:CBPD, PubMed

CD244, Complex: CD244:CD3Z, PubMed

CD28, Complex: CD3Z:CD28, PubMed

CD2, Complex: CD3Z:CD2, PubMed

CD38, Complex: CD3Z:CD38, PubMed

CD3D, Complex: CD3D:CD3Z, PubMed

CD3E, Complex: CD3E:CD3Z, PubMed

CD3Z, Complex: Transmembrane homodimer of glycoprotein CD3 zeta chain, PDBID: 2HAC

CD5, Complex: CD5:CD3Z, PubMed

CD8B, Complex: CD3Z:CD8B, PubMed

CTLA4, Complex: CTLA4:CD3Z, PubMed

ESYT1, Complex: CD3Z:ESYT1, PubMed

FCG3A, Complex: FCG3A:CD3Z, PubMed

LAT, Complex: LAT:CD3Z, PubMed

NCTR1, Complex: NCTR1:CD3Z, PubMed

NCTR3, Complex: CD3Z:NCTR3, PubMed

NLGN1, Complex: CD3Z:NLGN1, PubMed

PTPRC, Complex: PTPRC:CD3Z, PDBID: 1YGR, PubMed

RIC1, Complex: CD3Z:RIC1, PubMed

TFR1, Complex: TFR1:CD3Z, PubMed

TRAT1, Complex: CD3Z:TRAT1, PubMed

Domains

AA: 28-58, PDBID: 2HAC, Subunit B, Seq Identity:100%, T-cell surface glycoprotein CD3 zeta chain

AA: 69-88, PDBID: 1YGR, Subunit D, Seq Identity:100%, Immunoreceptor tyrosine-based activation motif

AA: 108-128, PDBID: 1CV9, Subunit A, Seq Identity:36%, Immunoreceptor tyrosine-based activation motif

AA: 139-158, PDBID: 1TCE, Subunit B, Seq Identity:100%, Immunoreceptor tyrosine-based activation motif

UniProt annotation for CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain
FUNCTION: Probable role in assembly and expression of the TCR complex as well as signal transduction upon antigen triggering.

SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta. CD3-zeta forms either homodimers or heterodimers with CD3-eta. Interacts with SLA and SLA2. Interacts with DOCK2 and TRAT1. Interacts with HIV-1; this interaction up- regulates the expression of the Fas ligand (FASLG) at the cell surface. Interacts with HIV-2 Nef protein; this interaction induces down-regulation of cell surface TCR/CD3 complexes. Interacts with SHB. Interacts with ZAP70. Interacts (tyrosine phosphorylated) with SHC1 (via SH2 domain). Interacts with PTPRC.

DOMAIN: The ITAM domains mediate interaction with SHB.

DISEASE: Immunodeficiency 25 (IMD25) OMIM: An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens. mutations affecting the gene represented in this entry.

UniProt features for CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain
SIGNAL 1 21
CHAIN 22 164 T-cell surface glycoprotein CD3 zeta chain.
DOMAIN 61 89 ITAM 1.
DOMAIN 100 128 ITAM 2.
DOMAIN 131 159 ITAM 3.
DISULFID 32 32 Interchain (Potential).
Amino Acid Sequence for CD3Z_HUMAN » T-cell surface glycoprotein CD3 zeta chain
MKWKALFTAA ILQAQLPITE AQSFGLLDPK LCYLLDGILF IYGVILTALF LRVKFSRSAD APAYQQGQNQ LYNELNLGRR EEYDVLDKRR GRDPEMGGKP QRRKNPQEGL YNELQKDKMA EAYSEIGMKG ERRRGKGHDG LYQGLSTATK DTYDALHMQA LPPR