CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain

CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain » T-cell receptor T3 gamma chain;
Hydrophobic Thickness 34.0 ± 1.4 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.0 kcal/mol
ΔGfold -14.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 112-139 (112-139)
Pathways

Chagas disease (KEGG)

Hematopoietic cell lineage (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Measles (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 1sy6 (A=23-103)
OPM none
Complexes

CD3G:CD3E:Q6PJA7_HUMAN

Interactions

CD3D, Complex: CD3G:CD3D, PubMed

CD3E, Complex: CD3E:CD3G, PDBID: 1sy6, PubMed

Domains

AA: 39-114, PDBID: 1XMW, Subunit A, Seq Identity:46%, T-cell surface glycoprotein CD3 delta chain

AA: 157-176, PDBID: 1TCE, Subunit B, Seq Identity:42%, Immunoreceptor tyrosine-based activation motif

UniProt annotation for CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain
FUNCTION: The CD3 complex mediates signal transduction.

SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

DOMAIN: A di-leucine motif and a tyrosine-based motif are individually sufficient to induce both endocytosis and delivery to lysosomes.

DISEASE: Immunodeficiency 17 (IMD17) OMIM: An autosomal recessive primary immunodeficiency characterized by highly variable clinical severity. Some patients have onset of severe recurrent infections in early infancy that may be lethal, whereas others may be only mildly affected or essentially asymptomatic into young adulthood. More severely affected patients may have evidence of autoimmune disease or enteropathy. The immunologic pattern is similar among patients, showing partial T-cell lymphopenia, decreased amounts of the CD3 complex, and impaired proliferative responses to T-cell receptor dependent stimuli. The phenotype in some patients is reminiscent of severe combined immunodeficiency. mutations affecting the gene represented in this entry.

UniProt features for CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain
SIGNAL 1 22
CHAIN 23 182 T-cell surface glycoprotein CD3 gamma chain.
DOMAIN 37 94 Ig-like.
DOMAIN 149 177 ITAM.
MOTIF 153 154 Di-leucine motif.
DISULFID 46 87
Amino Acid Sequence for CD3G_HUMAN » T-cell surface glycoprotein CD3 gamma chain
MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR RN