CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain

CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain » T-cell surface antigen T3/Leu-4 epsilon chain;
Hydrophobic Thickness 38.4 ± 4.2 Å
Tilt Angle 26 ± 0°
ΔGtransfer -27.5 kcal/mol
ΔGfold -14.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 124-152 (124-154)
Pathways

Chagas disease (KEGG)

Hematopoietic cell lineage (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Measles (KEGG)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 1xiw (A/E=23-126), 1sy6 (A=21-118), 1a81 (B/D...=186-203), 2rol (B=181-192)
OPM none
Complexes

CD3D:CD3E_HUMAN

CD3G:CD3E:Q6PJA7_HUMAN

Interactions

CD38, Complex: CD38:CD3E, PubMed

CD3D, Complex: CD3D:CD3E, PDBID: 1xiw

CD3G, Complex: CD3E:CD3G, PDBID: 1sy6, PubMed

CD3Z, Complex: CD3E:CD3Z, PubMed

CD79B, Complex: CD79B:CD3E, PubMed

LAT, Complex: LAT:CD3E, PubMed

TRAT1, Complex: CD3E:TRAT1, PubMed

Domains

AA: 36-127, PDBID: 1SY6, Subunit A, Seq Identity:100%, Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain

AA: 185-204, PDBID: 1A81, Subunit F, Seq Identity:100%, Immunoreceptor tyrosine-based activation motif

UniProt annotation for CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain
FUNCTION: The CD3 complex mediates signal transduction.

SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

DISEASE: Immunodeficiency 18 (IMD18) OMIM: An autosomal recessive primary immunodeficiency characterized by onset in infancy or early childhood of recurrent infections. The severity is variable, encompassing both a mild immunodeficiency and severe combined immunodeficiency (SCID), resulting in early death without bone marrow transplantation in some patients. Immunologic work-up of the IMD18 SCID patients shows a T cell-negative, B cell- positive, natural killer (NK) cell-positive phenotype, whereas T- cell development is not impaired in the mild form of IMD18. Note=The disease is caused by mutations affecting the gene represented in this entry.

UniProt features for CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain
SIGNAL 1 22
CHAIN 23 207 T-cell surface glycoprotein CD3 epsilon chain.
DOMAIN 32 112 Ig-like.
DOMAIN 178 205 ITAM.
DISULFID 49 98
Amino Acid Sequence for CD3E_HUMAN » T-cell surface glycoprotein CD3 epsilon chain
MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP PPVPNPDYEP IRKGQRDLYS GLNQRRI