CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain

CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain » T-cell receptor T3 delta chain;
Hydrophobic Thickness 33.2 ± 4.6 Å
Tilt Angle 3 ± 0°
ΔGtransfer -33.4 kcal/mol
ΔGfold -12.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 101-126 (101-128)
Pathways

Chagas disease (KEGG)

Hematopoietic cell lineage (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Measles (KEGG)

Primary immunodeficiency (KEGG)

T cell receptor signaling pathway (KEGG)

PDB 1xiw (B/F=23-100)
OPM none
Complexes

CD3D:CD3E_HUMAN

Interactions

CALX, Complex: CALX:CD3D, PubMed

CD3E, Complex: CD3D:CD3E, PDBID: 1xiw

CD3G, Complex: CD3G:CD3D, PubMed

CD3Z, Complex: CD3D:CD3Z, PubMed

CD8A, Complex: CD3D:CD8A, PubMed

CD8B, Complex: CD3D:CD8B, PubMed

ERLN2, Complex: CD3D:ERLN2, PubMed

Domains

AA: 30-103, PDBID: 1XIW, Subunit F, Seq Identity:100%, T-cell surface glycoprotein CD3 delta chain

AA: 146-165, PDBID: 1A81, Subunit F, Seq Identity:33%, Immunoreceptor tyrosine-based activation motif

UniProt annotation for CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain
FUNCTION: The CD3 complex mediates signal transduction.

SUBUNIT: The TCR/CD3 complex of T-lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

DISEASE: Severe combined immunodeficiency autosomal recessive T- cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) OMIM: A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. mutations affecting the gene represented in this entry.

DISEASE: Immunodeficiency 19 (IMD19) OMIM: An autosomal recessive form of severe combined immunodeficiency characterized by onset in early infancy of recurrent bacterial, viral, and fungal infections. Patients usually have chronic diarrhea, recurrent respiratory infections, and failure to thrive. Immunologic work-up shows a T-cell negative, B-cell positive, NK- cell positive phenotype. mutations affecting the gene represented in this entry.

UniProt features for CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain
SIGNAL 1 21
CHAIN 22 171 T-cell surface glycoprotein CD3 delta chain.
DOMAIN 138 166 ITAM.
DISULFID 37 73
Amino Acid Sequence for CD3D_HUMAN » T-cell surface glycoprotein CD3 delta chain
MEHSTFLSGL VLATLLSQVS PFKIPIEELE DRVFVNCNTS ITWVEGTVGT LLSDITRLDL GKRILDPRGI YRCNGTDIYK DKESTVQVHY RMCQSCVELD PATVAGIIVT DVIATLLLAL GVFCFAGHET GRLSGAADTQ ALLRNDQVYQ PLRDRDDAQY SHLGGNWARN K