CD34_HUMAN » Hematopoietic progenitor cell antigen CD34

CD34_HUMAN » Hematopoietic progenitor cell antigen CD34
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD34_HUMAN » Hematopoietic progenitor cell antigen CD34 »
Hydrophobic Thickness 31.6 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -39.6 kcal/mol
ΔGfold -16.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 289-312 (286-315)
Pathways

Cell adhesion molecules (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

CHST4, Complex: CHST4:CD34, PubMed

Domains

AA: 190-385, CD34/Podocalyxin family

UniProt annotation for CD34_HUMAN » Hematopoietic progenitor cell antigen CD34
FUNCTION: Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.

TISSUE SPECIFICITY: Selectively expressed on hematopoietic progenitor cells and the small vessel endothelium of a variety of tissues.

DEVELOPMENTAL STAGE: On early hematopoietic progenitor cells.

UniProt features for CD34_HUMAN » Hematopoietic progenitor cell antigen CD34
SIGNAL 1 31
CHAIN 32 385 Hematopoietic progenitor cell antigen CD34.
Amino Acid Sequence for CD34_HUMAN » Hematopoietic progenitor cell antigen CD34
MLVRRGARAG PRMPRGWTAL CLLSLLPSGF MSLDNNGTAT PELPTQGTFS NVSTNVSYQE TTTPSTLGST SLHPVSQHGN EATTNITETT VKFTSTSVIT SVYGNTNSSV QSQTSVISTV FTTPANVSTP ETTLKPSLSP GNVSDLSTTS TSLATSPTKP YTSSSPILSD IKAEIKCSGI REVKLTQGIC LEQNKTSSCA EFKKDRGEGL ARVLCGEEQA DADAGAQVCS LLLAQSEVRP QCLLLVLANR TEISSKLQLM KKHQSDLKKL GILDFTEQDV ASHQSYSQKT LIALVTSGAL LAVLGITGYF LMNRRSWSPT GERLGEDPYY TENGGGQGYS SGPGTSPEAQ GKASVNRGAQ ENGTGQATSR NGHSARQHVV ADTEL