CD33_HUMAN » Myeloid cell surface antigen CD33

CD33_HUMAN » Myeloid cell surface antigen CD33
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD33_HUMAN » Myeloid cell surface antigen CD33 » Sialic acid-binding Ig-like lectin 3;Siglec-3; gp67;
Hydrophobic Thickness 27.6 ± 1.8 Å
Tilt Angle 0 ± 0°
ΔGtransfer -38.9 kcal/mol
ΔGfold -16.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 263-285 (261-290)
Pathways

Hematopoietic cell lineage (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 24-139, PDBID: 2ZG1, Subunit A, Seq Identity:48%, Immunoglobulin V-set domain

AA: 146-227, PDBID: 2CR3, Subunit A, Seq Identity:26%, Immunoglobulin domain

UniProt annotation for CD33_HUMAN » Myeloid cell surface antigen CD33
FUNCTION: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).

SUBUNIT: Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.

TISSUE SPECIFICITY: Monocytic/myeloid lineage cells.

DOMAIN: Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2- containing phosphatases.

UniProt features for CD33_HUMAN » Myeloid cell surface antigen CD33
SIGNAL 1 17 Potential.
CHAIN 18 364 Myeloid cell surface antigen CD33.
DOMAIN 19 135 Ig-like V-type.
DOMAIN 145 228 Ig-like C2-type.
MOTIF 338 343 ITIM motif 1.
MOTIF 356 361 ITIM motif 2.
DISULFID 36 169 By similarity.
DISULFID 41 101 By similarity.
DISULFID 163 212 Potential.
Amino Acid Sequence for CD33_HUMAN » Myeloid cell surface antigen CD33
MPLLLLLPLL WAGALAMDPN FWLQVQESVT VQEGLCVLVP CTFFHPIPYY DKNSPVHGYW FREGAIISRD SPVATNKLDQ EVQEETQGRF RLLGDPSRNN CSLSIVDARR RDNGSYFFRM ERGSTKYSYK SPQLSVHVTD LTHRPKILIP GTLEPGHSKN LTCSVSWACE QGTPPIFSWL SAAPTSLGPR TTHSSVLIIT PRPQDHGTNL TCQVKFAGAG VTTERTIQLN VTYVPQNPTT GIFPGDGSGK QETRAGVVHG AIGGAGVTAL LALCLCLIFF IVKTHRRKAA RTAVGRNDTH PTTGSASPKH QKKSKLHGPT ETSSCSGAAP TVEMDEELHY ASLNFHGMNP SKDTSTEYSE VRTQ