CD320_HUMAN » CD320 antigen

CD320_HUMAN » CD320 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD320_HUMAN » CD320 antigen » 8D6 antigen;FDC-signaling molecule 8D6;FDC-SM-8D6; Transcobalamin receptor;TCblR;
Hydrophobic Thickness 34.8 ± 1.2 Å
Tilt Angle 5 ± 2°
ΔGtransfer -39.6 kcal/mol
ΔGfold -20.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 229-253 (226-260)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 52-89, PDBID: 1CR8, Subunit A, Seq Identity:60%, Low-density lipoprotein receptor domain class A

AA: 130-167, PDBID: 1CR8, Subunit A, Seq Identity:56%, Low-density lipoprotein receptor domain class A

UniProt annotation for CD320_HUMAN » CD320 antigen
FUNCTION: Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC). CD320 augments the proliferation of PC precursors generated by IL-10. Receptor for the cellular uptake of transcobalamin bound cobalamin.

TISSUE SPECIFICITY: Expressed abundantly on follicular dendritic cells (FDCs).

DISEASE: Methylmalonic aciduria type TCblR (MMATC) OMIM: A metabolic disorder characterized by increased blood C3- acylcarnitine levels, elevated methylmalonate and homocysteine, and low uptake of transcobalamin-bound cobalamin, but normal conversion to adenosylcobalamin and methylcobalamin. Plasma vitamin B12 and total homocysteine are normal. mutations affecting the gene represented in this entry.

UniProt features for CD320_HUMAN » CD320 antigen
SIGNAL 1 35
CHAIN 36 282 CD320 antigen.
DOMAIN 53 90 LDL-receptor class A 1.
DOMAIN 131 168 LDL-receptor class A 2.
DISULFID 54 67 By similarity.
DISULFID 61 80 By similarity.
DISULFID 74 89 By similarity.
DISULFID 132 145 By similarity.
DISULFID 139 158 By similarity.
DISULFID 152 167 By similarity.
Amino Acid Sequence for CD320_HUMAN » CD320 antigen
MSGGWMAQVG AWRTGALGLA LLLLLGLGLG LEAAASPLST PTSAQAAGPS SGSCPPTKFQ CRTSGLCVPL TWRCDRDLDC SDGSDEEECR IEPCTQKGQC PPPPGLPCPC TGVSDCSGGT DKKLRNCSRL ACLAGELRCT LSDDCIPLTW RCDGHPDCPD SSDELGCGTN EILPEGDATT MGPPVTLESV TSLRNATTMG PPVTLESVPS VGNATSSSAG DQSGSPTAYG VIAAAAVLSA SLVTATLLLL SWLRAQERLR PLGLLVAMKE SLLLSEQKTS LP