CD302_HUMAN » CD302 antigen

CD302_HUMAN » CD302 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD302_HUMAN » CD302 antigen » C-type lectin BIMLEC;C-type lectin domain family 13 member A;DEC205-associated C-type lectin 1;Type I transmembrane C-type lectin receptor DCL-1;
Hydrophobic Thickness 38.0 ± 3.8 Å
Tilt Angle 9 ± 8°
ΔGtransfer -27.2 kcal/mol
ΔGfold -25.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 169-194 (166-199)
Pathways none
PDB none
OPM none
Complexes none
Interactions

FATE1, Complex: CD302:FATE1

Domains

AA: 45-155, PDBID: 1EGG, Subunit A, Seq Identity:27%, Lectin C-type domain

UniProt annotation for CD302_HUMAN » CD302 antigen
FUNCTION: Potential multifunctional C-type lectin receptor that may play roles in endocytosis and phagocytosis as well as in cell adhesion and migration.

TISSUE SPECIFICITY: Expressed at moderate levels in monocytes, myeloid blood dendritic cells and granulocytes and at low levels in plasmacytoid blood dendritic cells, monocyte-derived ma crophages and monocyte-derived dendritic cells, with no expression detected in T-lymphocytes, B-lymphocytes and natural killer cells (at protein level). Expressed widely in different tissues, with highest expression levels in liver, lung, peripheral blood leukocytes and spleen, and lowest levels in neuronal tissues, skeletal muscle and ovary. Isoform 2 and isoform 3 are expressed in malignant Hodgkin lymphoma cells called Hodgkin and Reed- Sternberg (HRS) cells.

DEVELOPMENTAL STAGE: Expressed at relatively high levels in fetal lung, liver, spleen and kidney with lower expression levels detected in heart, thymus and brain.

MISCELLANEOUS: Isoform 2 and isoform 3 are produced in HRS cells by a transcriptional control mechanism which cotranscribe an mRNA containing LY75 and CD302 prior to generating the intergenically spliced mRNA to produce LY75/CD302 fusion proteins.

UniProt features for CD302_HUMAN » CD302 antigen
SIGNAL 1 22 Potential.
CHAIN 23 232 CD302 antigen.
DOMAIN 32 152 C-type lectin.
DISULFID 128 143 By similarity.
Amino Acid Sequence for CD302_HUMAN » CD302 antigen
MLRAALPALL LPLLGLAAAA VADCPSSTWI QFQDSCYIFL QEAIKVESIE DVRNQCTDHG ADMISIHNEE ENAFILDTLK KQWKGPDDIL LGMFYDTDDA SFKWFDNSNM TFDKWTDQDD DEDLVDTCAF LHIKTGEWKK GNCEVSSVEG TLCKTAIPYK RKYLSDNHIL ISALVIASTV ILTVLGAIIW FLYKKHSDSR FTTVFSTAPQ SPYNEDCVLV VGEENEYPVQ FD