CD2_HUMAN » T-cell surface antigen CD2

CD2_HUMAN » T-cell surface antigen CD2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD2_HUMAN » T-cell surface antigen CD2 » Erythrocyte receptor;LFA-2;LFA-3 receptor;Rosette receptor;T-cell surface antigen T11/Leu-5;
Hydrophobic Thickness 38.4 ± 2.4 Å
Tilt Angle 6 ± 3°
ΔGtransfer -44.1 kcal/mol
ΔGfold -18.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 211-235 (210-243)
Pathways

Cell adhesion molecules (KEGG)

Hematopoietic cell lineage (KEGG)

Hemostasis (Reactome)

PDB 1cdb (25-129), 1gya (25-129), 1hnf (25-206), 1qa9 (A/C=28-129), 1l2z (B=294-304), 2j7i (C/D=324-333), 2j6o (C=324-333)
OPM none
Complexes

LFA3:CD2_HUMAN

CD2:CD2_RAT

Interactions

CD2, Complex: Homodimer of CD2 antigen, PDBID: 1HNG

CD3Z, Complex: CD3Z:CD2, PubMed

CD4, Complex: CD4:CD2, PubMed

CD5, Complex: CD2:CD5, PubMed

LFA3, Complex: CD2:LFA3, PDBID: 1qa9, PubMed

PTPRC, Complex: PTPRC:CD2, PubMed

Domains

AA: 28-127, PDBID: 1CDB, Subunit A, Seq Identity:100%, Immunoglobulin V-set domain

AA: 135-205, PDBID: 1HNF, Subunit A, Seq Identity:100%, Immunoglobulin C2-set domain

UniProt annotation for CD2_HUMAN » T-cell surface antigen CD2
FUNCTION: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function.

SUBUNIT: Interacts with CD2AP (By similarity). Interacts with PSTPIP1.

UniProt features for CD2_HUMAN » T-cell surface antigen CD2
SIGNAL 1 24
CHAIN 25 351 T-cell surface antigen CD2.
DOMAIN 25 128 Ig-like V-type.
DOMAIN 129 209 Ig-like C2-type.
REGION 61 75 LFA-3 (CD58) binding region 1.
REGION 106 120 LFA-3 (CD58) binding region 2.
DISULFID 139 203
DISULFID 146 186
Amino Acid Sequence for CD2_HUMAN » T-cell surface antigen CD2
MSFPCKFVAS FLLIFNVSSK GAVSKEITNA LETWGALGQD INLDIPSFQM SDDIDDIKWE KTSDKKKIAQ FRKEKETFKE KDTYKLFKNG TLKIKHLKTD DQDIYKVSIY DTKGKNVLEK IFDLKIQERV SKPKISWTCI NTTLTCEVMN GTDPELNLYQ DGKHLKLSQR VITHKWTTSL SAKFKCTAGN KVSKESSVEP VSCPEKGLDI YLIIGICGGG SLLMVFVALL VFYITKRKKQ RSRRNDEELE TRAHRVATEE RGRKPHQIPA STPQNPATSQ HPPPPPGHRS QAPSHRPPPP GHRVQHQPQK RPPAPSGTQV HQQKGPPLPR PRVQPKPPHG AAENSLSPSS N