CD28_HUMAN » T-cell-specific surface glycoprotein CD28

CD28_HUMAN » T-cell-specific surface glycoprotein CD28
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD28_HUMAN » T-cell-specific surface glycoprotein CD28 » TP44;
Hydrophobic Thickness 42.0 ± 1.4 Å
Tilt Angle 3 ± 1°
ΔGtransfer -46.5 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 152-180 (152-184)
Pathways

Allograft rejection (KEGG)

Autoimmune thyroid disease (KEGG)

Cell adhesion molecules (KEGG)

Graft-versus-host disease (KEGG)

Immune System (Reactome)

Intestinal immune network for IgA production (KEGG)

Measles (KEGG)

Rheumatoid arthritis (KEGG)

Signal Transduction (Reactome)

Systemic lupus erythematosus (KEGG)

T cell receptor signaling pathway (KEGG)

Type I diabetes mellitus (KEGG)

Viral myocarditis (KEGG)

PDB 3wa4 (B=189-196), 1yjd (C=17-152)
OPM 1yjd
Complexes none
Interactions

CD3Z, Complex: CD3Z:CD28, PubMed

CD4, Complex: CD4:CD28, PubMed

CD80, Complex: CD28:CD80, PubMed

CD86, Complex: CD28:CD86, PubMed

PTPRC, Complex: CD28:PTPRC, PubMed

Domains

AA: 23-139, PDBID: 1YJD, Subunit C, Seq Identity:100%, ICOS V-set domain

UniProt annotation for CD28_HUMAN » T-cell-specific surface glycoprotein CD28
FUNCTION: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival.

SUBUNIT: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2.

TISSUE SPECIFICITY: Expressed in T-cells and plasma cells, but not in less mature B-cells.

UniProt features for CD28_HUMAN » T-cell-specific surface glycoprotein CD28
SIGNAL 1 18
CHAIN 19 220 T-cell-specific surface glycoprotein CD28.
DOMAIN 28 137 Ig-like V-type.
DISULFID 40 112
DISULFID 66 86
Amino Acid Sequence for CD28_HUMAN » T-cell-specific surface glycoprotein CD28
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS