CD27_HUMAN » CD27 antigen

CD27_HUMAN » CD27 antigen
Magnify CD27_HUMAN » CD27 antigenEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD27_HUMAN » CD27 antigen » CD27L receptor;T-cell activation antigen CD27;T14;Tumor necrosis factor receptor superfamily member 7;
Hydrophobic Thickness 33.6 ± 2.4 Å
Tilt Angle 1 ± 1°
ΔGtransfer -48.1 kcal/mol
ΔGfold -20.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 189-211 (187-217)
Pathways

Cytokine-cytokine receptor interaction (KEGG)

PDB none
OPM none
Complexes none
Interactions

CD5, Complex: CD5:CD27, PubMed

CD70, Complex: CD70:CD27, PubMed

Domains

AA: 65-104, PDBID: 3THM, Subunit F, Seq Identity:38%, TNFR/NGFR cysteine-rich region

UniProt annotation for CD27_HUMAN » CD27 antigen
FUNCTION: Receptor for CD70/CD27L. May play a role in survival of activated T-cells. May play a role in apoptosis through association with SIVA1.

SUBUNIT: Homodimer. Interacts with SIVA1 and TRAF2.

TISSUE SPECIFICITY: Found in most T-lymphocytes.

DISEASE: Lymphoproliferative syndrome 2 (LPFS2) OMIM: An autosomal recessive immunodeficiency disorder associated with persistent symptomatic EBV viremia, hypogammaglobulinemia, and impaired T-cell-dependent B-cell responses and T-cell dysfunction. The phenotype is highly variable, ranging from asymptomatic borderline-low hypogammaglobulinemia, to a full-blown symptomatic systemic inflammatory response with life-threatening EBV-related complications, including hemophagocytic lymphohistiocytosis, a lymphoproliferative disorder, and malignant lymphoma requiring stem cell transplantation. mutations affecting the gene represented in this entry.

UniProt features for CD27_HUMAN » CD27 antigen
SIGNAL 1 19
CHAIN 20 260 CD27 antigen.
REPEAT 26 63 TNFR-Cys 1.
REPEAT 64 104 TNFR-Cys 2.
REPEAT 105 141 TNFR-Cys 3.
DISULFID 27 39 By similarity.
DISULFID 40 53 By similarity.
DISULFID 43 62 By similarity.
DISULFID 65 81 By similarity.
DISULFID 84 96 By similarity.
DISULFID 87 104 By similarity.
DISULFID 106 117 By similarity.
DISULFID 112 120 By similarity.
Amino Acid Sequence for CD27_HUMAN » CD27 antigen
MARPHPWWLC VLGTLVGLSA TPAPKSCPER HYWAQGKLCC QMCEPGTFLV KDCDQHRKAA QCDPCIPGVS FSPDHHTRPH CESCRHCNSG LLVRNCTITA NAECACRNGW QCRDKECTEC DPLPNPSLTA RSSQALSPHP QPTHLPYVSE MLEARTAGHM QTLADFRQLP ARTLSTHWPP QRSLCSSDFI RILVIFSGMF LVFTLAGALF LHQRRKYRSN KGESPVEPAE PCRYSCPREE EGSTIPIQED YRKPEPACSP