CD276_HUMAN » CD276 antigen

CD276_HUMAN » CD276 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD276_HUMAN » CD276 antigen » 4Ig-B7-H3;B7 homolog 3;B7-H3; Costimulatory molecule;
Hydrophobic Thickness 36.0 ± 1.2 Å
Tilt Angle 0 ± 0°
ΔGtransfer -44.7 kcal/mol
ΔGfold -22.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 466-492 (464-493)
Pathways

Cell adhesion molecules (KEGG)

PDB none
OPM none
Complexes none
Interactions

RYK, Complex: CD276:RYK, PubMed

Domains

AA: 32-138, PDBID: 4I0K, Subunit A, Seq Identity:87%, Immunoglobulin V-set domain

AA: 144-224, PDBID: 4I0K, Subunit A, Seq Identity:82%, Immunoglobulin domain

AA: 250-356, PDBID: 4I0K, Subunit A, Seq Identity:92%, Immunoglobulin V-set domain

AA: 362-442, PDBID: 4I0K, Subunit A, Seq Identity:94%, Immunoglobulin domain

UniProt annotation for CD276_HUMAN » CD276 antigen
FUNCTION: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.

SUBUNIT: Interacts with TREML2 and this interaction enhances T- cell activation.

TISSUE SPECIFICITY: Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.

INDUCTION: By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.

MISCELLANEOUS: B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)- C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.

UniProt features for CD276_HUMAN » CD276 antigen
SIGNAL 1 28
CHAIN 29 534 CD276 antigen.
DOMAIN 29 139 Ig-like V-type 1.
DOMAIN 145 238 Ig-like C2-type 1.
DOMAIN 243 357 Ig-like V-type 2.
DOMAIN 363 456 Ig-like C2-type 2.
DISULFID 50 122 By similarity.
DISULFID 165 220 By similarity.
DISULFID 268 340 By similarity.
DISULFID 383 438 By similarity.
Amino Acid Sequence for CD276_HUMAN » CD276 antigen
MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA