CD248_HUMAN » Endosialin

CD248_HUMAN » Endosialin
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD248_HUMAN » Endosialin » Tumor endothelial marker 1;
Hydrophobic Thickness 36.0 ± 3.8 Å
Tilt Angle 13 ± 8°
ΔGtransfer -29.8 kcal/mol
ΔGfold -20.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 686-711 (684-713)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 40-158, PDBID: 1EGG, Subunit A, Seq Identity:30%, Lectin C-type domain

AA: 235-271, PDBID: 1AUT, Subunit L, Seq Identity:50%, Coagulation Factor Xa inhibitory site

UniProt annotation for CD248_HUMAN » Endosialin
FUNCTION: May play a role in tumor angiogenesis.

TISSUE SPECIFICITY: Expressed in tumor endothelial cells but absent or barely detectable in normal endothelial cells. Expressed in metastatic lesions of the liver and during angiogenesis of corpus luteum formation and wound healing. Expressed in vascular endothelial cells of malignant tumors but not in normal blood vessels. Expressed in stromal fibroblasts.

UniProt features for CD248_HUMAN » Endosialin
SIGNAL 1 17 Potential.
CHAIN 18 757 Endosialin.
DOMAIN 30 156 C-type lectin.
DOMAIN 162 232 Sushi.
DOMAIN 312 351 EGF-like; calcium-binding (Potential).
DISULFID 131 147 By similarity.
DISULFID 316 326 By similarity.
DISULFID 322 335 By similarity.
DISULFID 337 350 By similarity.
Amino Acid Sequence for CD248_HUMAN » Endosialin
MLLRLLLAWA AAGPTLGQDP WAAEPRAACG PSSCYALFPR RRTFLEAWRA CRELGGDLAT PRTPEEAQRV DSLVGAGPAS RLLWIGLQRQ ARQCQLQRPL RGFTWTTGDQ DTAFTNWAQP ASGGPCPAQR CVALEASGEH RWLEGSCTLA VDGYLCQFGF EGACPALQDE AGQAGPAVYT TPFHLVSTEF EWLPFGSVAA VQCQAGRGAS LLCVKQPEGG VGWSRAGPLC LGTGCSPDNG GCEHECVEEV DGHVSCRCTE GFRLAADGRS CEDPCAQAPC EQQCEPGGPQ GYSCHCRLGF RPAEDDPHRC VDTDECQIAG VCQQMCVNYV GGFECYCSEG HELEADGISC SPAGAMGAQA SQDLGDELLD DGEDEEDEDE AWKAFNGGWT EMPGILWMEP TQPPDFALAY RPSFPEDREP QIPYPEPTWP PPLSAPRVPY HSSVLSVTRP VVVSATHPTL PSAHQPPVIP ATHPALSRDH QIPVIAANYP DLPSAYQPGI LSVSHSAQPP AHQPPMISTK YPELFPAHQS PMFPDTRVAG TQTTTHLPGI PPNHAPLVTT LGAQLPPQAP DALVLRTQAT QLPIIPTAQP SLTTTSRSPV SPAHQISVPA ATQPAALPTL LPSQSPTNQT SPISPTHPHS KAPQIPREDG PSPKLALWLP SPAPTAAPTA LGEAGLAEHS QRDDRWLLVA LLVPTCVFLV VLLALGIVYC TRCGPHAPNK RITDCYRWVI HAGSKSPTEP MPPRGSLTGV QTCRTSV