CD226_HUMAN » CD226 antigen

CD226_HUMAN » CD226 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD226_HUMAN » CD226 antigen » DNAX accessory molecule 1;DNAM-1;
Hydrophobic Thickness 34.4 ± 2.2 Å
Tilt Angle 29 ± 0°
ΔGtransfer -31.3 kcal/mol
ΔGfold -27.1 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 251-276 (246-282)
Pathways

Cell adhesion molecules (KEGG)

Immune System (Reactome)

PDB none
OPM none
Complexes none
Interactions

ITB2, Complex: CD226:ITB2, PubMed

PVRL2, Complex: PVRL2:CD226, PubMed

PVR, Complex: PVR:CD226, PubMed

Domains

AA: 24-127, PDBID: 3ALP, Subunit A, Seq Identity:27%, Immunoglobulin V-set domain

AA: 136-241, PDBID: 4FOM, Subunit A, Seq Identity:26%, Immunoglobulin V-set domain

UniProt annotation for CD226_HUMAN » CD226 antigen
FUNCTION: Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.

SUBUNIT: Interacts with PVR and PVRL2.

TISSUE SPECIFICITY: Expressed by peripheral blood T-lymphocytes.

UniProt features for CD226_HUMAN » CD226 antigen
SIGNAL 1 18
CHAIN 19 336 CD226 antigen.
DOMAIN 19 126 Ig-like C2-type 1.
DOMAIN 135 239 Ig-like C2-type 2.
DISULFID 37 108 Potential.
DISULFID 152 222 Potential.
Amino Acid Sequence for CD226_HUMAN » CD226 antigen
MDYPTLLLAL LHVYRALCEE VLWHTSVPFA ENMSLECVYP SMGILTQVEW FKIGTQQDSI AIFSPTHGMV IRKPYAERVY FLNSTMASNN MTLFFRNASE DDVGYYSCSL YTYPQGTWQK VIQVVQSDSF EAAVPSNSHI VSEPGKNVTL TCQPQMTWPV QAVRWEKIQP RQIDLLTYCN LVHGRNFTSK FPRQIVSNCS HGRWSVIVIP DVTVSDSGLY RCYLQASAGE NETFVMRLTV AEGKTDNQYT LFVAGGTVLL LLFVISITTI IVIFLNRRRR RERRDLFTES WDTQKAPNNY RSPISTGQPT NQSMDDTRED IYVNYPTFSR RPKTRV