CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated

CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated
Magnify CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associatedEnlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated » hCD1e; R2G1
Hydrophobic Thickness 34.4 ± 3.2 Å
Tilt Angle 9 ± 6°
ΔGtransfer -27.2 kcal/mol
ΔGfold -22.5 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 305-329 (304-330)
Pathways

Hematopoietic cell lineage (KEGG)

PDB 3s6c (32-303)
OPM none
Complexes none
Interactions none
Domains

AA: 20-204, PDBID: 3S6C, Subunit A, Seq Identity:100%, MHC-I family domain

AA: 219-292, PDBID: 3S6C, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated
FUNCTION: T-cell surface glycoprotein CD1e, soluble binds diacetylated lipids, including phosphatidyl inositides and diacylated sulfoglycolipids, and is required for the presentation of glycolipid antigens on the cell surface. The membrane- associated form is not active.

SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). The association with B2M appears to be facilitated by the presence of the propeptide.

TISSUE SPECIFICITY: Expressed on cortical thymocytes, dendritic cells, Langerhans cells, on certain T-cell leukemias, and in various other tissues.

UniProt features for CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated
SIGNAL 1 19 Potential.
CHAIN 20 388 T-cell surface glycoprotein CD1e, membrane-associated.
PROPEP 20 31 Removed in sCD1e.
CHAIN 32 388 T-cell surface glycoprotein CD1e, soluble.
DOMAIN 191 301 Ig-like.
DISULFID 230 285 By similarity.
Amino Acid Sequence for CD1E_HUMAN » T-cell surface glycoprotein CD1e, membrane-associated
MLLLFLLFEG LCCPGENTAA PQALQSYHLA AEEQLSFRML QTSSFANHSW AHSEGSGWLG DLQTHGWDTV LGTIRFLKPW SHGNFSKQEL KNLQSLFQLY FHSFIQIVQA SAGQFQLEYP FEIQILAGCR MNAPQIFLNM AYQGSDFLSF QGISWEPSPG AGIRAQNICK VLNRYLDIKE ILQSLLGHTC PRFLAGLMEA GESELKRKVK PEAWLSCGPS PGPGRLQLVC HVSGFYPKPV WVMWMRGEQE QRGTQRGDVL PNADETWYLR ATLDVAAGEA AGLSCRVKHS SLGGHDLIIH WGGYSIFLIL ICLTVIVTLV ILVVVDSRLK KQSSNKNILS PHTPSPVFLM GANTQDTKNS RHQFCLAQVS WIKNRVLKKW KTRLNQLW