CD1D_HUMAN » Antigen-presenting glycoprotein CD1d

CD1D_HUMAN » Antigen-presenting glycoprotein CD1d
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD1D_HUMAN » Antigen-presenting glycoprotein CD1d » R3G1;
Hydrophobic Thickness 34.4 ± 2.0 Å
Tilt Angle 36 ± 29°
ΔGtransfer -27.8 kcal/mol
ΔGfold -25.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 298-326 (298-329)
Pathways

Amoebiasis (KEGG)

Hematopoietic cell lineage (KEGG)

PDB 3u0p (A/C/E=21-295), 1zt4 (A/C=19-299), 4mng (A/C=21-201), 3huj (A/C=21-295), 3sdx (A/C=24-295), 2po6 (A/E=24-295), 4mq7 (A=21-202), 3vwj (A=21-295), 3vwk (A=21-295), 4lhu (A=24-295), 4wo4 (A=24-295), 3tzv (C=21-295), 4en3 (C=21-295)
OPM none
Complexes

TRGC1:Q6PJ56:CD1D:B2MG_HUMAN

TCA:TRBC1:CD1D:B2MG_HUMAN

TCA:CD1D:B2MG_HUMAN

Interactions

CALX, Complex: PDIA3:CD1D:CALX:CALR, PubMed

DRA, Complex: DRA:HG2A:CD1D:2B13.2B1F.2B1G, PubMed

HG2A, Complex: CD1D:HG2A, PubMed

LIRB2, Complex: LIRB2:CD1D, PubMed

P4HTM, Complex: P4HTM:CD1D, PubMed

PTPRC, Complex: PTPRC:CD1D, PubMed

TCA, Complex: B2MG:CD1D:TCA, PDBID: 2po6

TRBC2, Complex: TRBC2:CD1D, PubMed

TRDC, Complex: TRGC1:TRDC:CD1D, PubMed

TRGC1, Complex: TRGC1:Q6PJ56:CD1D:B2MG, PDBID: 4LHU

Domains

AA: 1-198, PDBID: 1ZT4, Subunit C, Seq Identity:100%, MHC-I family domain

AA: 209-286, PDBID: 1ZT4, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for CD1D_HUMAN » Antigen-presenting glycoprotein CD1d
FUNCTION: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells.

SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with MHC II.

TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

UniProt features for CD1D_HUMAN » Antigen-presenting glycoprotein CD1d
SIGNAL 1 19 By similarity.
CHAIN 20 335 Antigen-presenting glycoprotein CD1d.
DOMAIN 185 292 Ig-like.
MOTIF 331 334 Internalization signal.
DISULFID 120 184
DISULFID 224 279
Amino Acid Sequence for CD1D_HUMAN » Antigen-presenting glycoprotein CD1d
MGCLLFLLLW ALLQAWGSAE VPQRLFPLRC LQISSFANSS WTRTDGLAWL GELQTHSWSN DSDTVRSLKP WSQGTFSDQQ WETLQHIFRV YRSSFTRDVK EFAKMLRLSY PLELQVSAGC EVHPGNASNN FFHVAFQGKD ILSFQGTSWE PTQEAPLWVN LAIQVLNQDK WTRETVQWLL NGTCPQFVSG LLESGKSELK KQVKPKAWLS RGPSPGPGRL LLVCHVSGFY PKPVWVKWMR GEQEQQGTQP GDILPNADET WYLRATLDVV AGEAAGLSCR VKHSSLEGQD IVLYWGGSYT SMGLIALAVL ACLLFLLIVG FTSRFKRQTS YQGVL