CD1C_HUMAN » T-cell surface glycoprotein CD1c

CD1C_HUMAN » T-cell surface glycoprotein CD1c
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD1C_HUMAN » T-cell surface glycoprotein CD1c »
Hydrophobic Thickness 32.4 ± 2.0 Å
Tilt Angle 24 ± 3°
ΔGtransfer -26.4 kcal/mol
ΔGfold -23.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 304-326 (304-330)
Pathways

Hematopoietic cell lineage (KEGG)

PDB 3ov6 (19-201), 4ono (24-201)
OPM none
Complexes none
Interactions none
Domains

AA: 1-199, PDBID: 3OV6, Subunit A, Seq Identity:100%, MHC-I family domain

AA: 206-287, PDBID: 1ONQ, Subunit C, Seq Identity:69%, Immunoglobulin C1-set domain

UniProt annotation for CD1C_HUMAN » T-cell surface glycoprotein CD1c
FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

SUBUNIT: Heterodimer with B2M (beta-2-microglobulin).

TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface.

UniProt features for CD1C_HUMAN » T-cell surface glycoprotein CD1c
SIGNAL 1 17 Potential.
CHAIN 18 333 T-cell surface glycoprotein CD1c.
DOMAIN 206 296 Ig-like.
MOTIF 329 332 Internalization signal.
DISULFID 120 185
DISULFID 225 280 By similarity.
Amino Acid Sequence for CD1C_HUMAN » T-cell surface glycoprotein CD1c
MLFLQFLLLA LLLPGGDNAD ASQEHVSFHV IQIFSFVNQS WARGQGSGWL DELQTHGWDS ESGTIIFLHN WSKGNFSNEE LSDLELLFRF YLFGLTREIQ DHASQDYSKY PFEVQVKAGC ELHSGKSPEG FFQVAFNGLD LLSFQNTTWV PSPGCGSLAQ SVCHLLNHQY EGVTETVYNL IRSTCPRFLL GLLDAGKMYV HRQVRPEAWL SSRPSLGSGQ LLLVCHASGF YPKPVWVTWM RNEQEQLGTK HGDILPNADG TWYLQVILEV ASEEPAGLSC RVRHSSLGGQ DIILYWGHHF SMNWIALVVI VPLVILIVLV LWFKKHCSYQ DIL