CD1B_HUMAN » T-cell surface glycoprotein CD1b

CD1B_HUMAN » T-cell surface glycoprotein CD1b
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD1B_HUMAN » T-cell surface glycoprotein CD1b »
Hydrophobic Thickness 35.2 ± 3.2 Å
Tilt Angle 2 ± 1°
ΔGtransfer -24.6 kcal/mol
ΔGfold -21.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 301-324 (298-327)
Pathways

Hematopoietic cell lineage (KEGG)

PDB 4ono (201-295), 3ov6 (27-295), 3t8x (A/C=19-298), 1gzp (A=18-295), 1gzq (A=18-295), 1uqs (A=18-295), 2h26 (A=19-298)
OPM none
Complexes none
Interactions

CD1A, Complex: CD1B:CD1C:CD8A:CD1A, PubMed

Domains

AA: 1-198, PDBID: 1GZP, Subunit A, Seq Identity:100%, MHC-I family domain

AA: 210-286, PDBID: 1GZP, Subunit A, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for CD1B_HUMAN » T-cell surface glycoprotein CD1b
FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with saposin C.

TISSUE SPECIFICITY: Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes or lysosomes, before trafficking back to the cell surface. Interaction with saposin C is required for the loading of bacterial lipid antigens onto CD1B in the lysosome.

UniProt features for CD1B_HUMAN » T-cell surface glycoprotein CD1b
SIGNAL 1 17 Potential.
CHAIN 18 333 T-cell surface glycoprotein CD1b.
DOMAIN 185 295 Ig-like.
MOTIF 329 332 Internalization signal.
DISULFID 120 184
DISULFID 149 163
DISULFID 224 279
Amino Acid Sequence for CD1B_HUMAN » T-cell surface glycoprotein CD1b
MLLLPFQLLA VLFPGGNSEH AFQGPTSFHV IQTSSFTNST WAQTQGSGWL DDLQIHGWDS DSGTAIFLKP WSKGNFSDKE VAELEEIFRV YIFGFAREVQ DFAGDFQMKY PFEIQGIAGC ELHSGGAIVS FLRGALGGLD FLSVKNASCV PSPEGGSRAQ KFCALIIQYQ GIMETVRILL YETCPRYLLG VLNAGKADLQ RQVKPEAWLS SGPSPGPGRL QLVCHVSGFY PKPVWVMWMR GEQEQQGTQL GDILPNANWT WYLRATLDVA DGEAAGLSCR VKHSSLEGQD IILYWRNPTS IGSIVLAIIV PSLLLLLCLA LWYMRRRSYQ NIP