CD1A_HUMAN » T-cell surface glycoprotein CD1a

CD1A_HUMAN » T-cell surface glycoprotein CD1a
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD1A_HUMAN » T-cell surface glycoprotein CD1a » T-cell surface antigen T6/Leu-6;hTa1 thymocyte antigen;
Hydrophobic Thickness 34.8 ± 3.2 Å
Tilt Angle 2 ± 0°
ΔGtransfer -25.8 kcal/mol
ΔGfold -21.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 300-323 (295-323)
Pathways

Hematopoietic cell lineage (KEGG)

PDB 1onq (A/C=18-294), 1xz0 (A/C=18-294), 4x6c (A/C=21-295), 4x6d (A/C=21-295), 4x6e (A=21-295), 4x6f (A=21-295)
OPM none
Complexes none
Interactions

CD1B, Complex: CD1B:CD1C:CD8A:CD1A, PubMed

Domains

AA: 1-197, PDBID: 1ONQ, Subunit C, Seq Identity:100%, MHC-I family domain

AA: 209-285, PDBID: 1ONQ, Subunit C, Seq Identity:100%, Immunoglobulin C1-set domain

UniProt annotation for CD1A_HUMAN » T-cell surface glycoprotein CD1a
FUNCTION: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

SUBUNIT: Heterodimer with B2M (beta-2-microglobulin). Interacts with CD74.

TISSUE SPECIFICITY: Expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues.

MISCELLANEOUS: During protein synthesis and maturation, CD1 family members bind endogenous lipids that are replaced by lipid or glycolipid antigens when the proteins are internalized and pass through endosomes, before trafficking back to the cell surface.

UniProt features for CD1A_HUMAN » T-cell surface glycoprotein CD1a
SIGNAL 1 16
CHAIN 17 327 T-cell surface glycoprotein CD1a.
DOMAIN 184 291 Ig-like.
REGION 90 94 Glycolipid binding.
DISULFID 119 183 By similarity.
DISULFID 223 278
Amino Acid Sequence for CD1A_HUMAN » T-cell surface glycoprotein CD1a
MLFLLLPLLA VLPGDGNADG LKEPLSFHVI WIASFYNHSW KQNLVSGWLS DLQTHTWDSN SSTIVFLWPW SRGNFSNEEW KELETLFRIR TIRSFEGIRR YAHELQFEYP FEIQVTGGCE LHSGKVSGSF LQLAYQGSDF VSFQNNSWLP YPVAGNMAKH FCKVLNQNQH ENDITHNLLS DTCPRFILGL LDAGKAHLQR QVKPEAWLSH GPSPGPGHLQ LVCHVSGFYP KPVWVMWMRG EQEQQGTQRG DILPSADGTW YLRATLEVAA GEAADLSCRV KHSSLEGQDI VLYWEHHSSV GFIILAVIVP LLLLIGLALW FRKRCFC