CD19_HUMAN » B-lymphocyte antigen CD19

CD19_HUMAN » B-lymphocyte antigen CD19
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD19_HUMAN » B-lymphocyte antigen CD19 » B-lymphocyte surface antigen B4;Differentiation antigen CD19;T-cell surface antigen Leu-12;
Hydrophobic Thickness 33.2 ± 3.2 Å
Tilt Angle 25 ± 3°
ΔGtransfer -18.1 kcal/mol
ΔGfold -13.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome
Topology Out
TM Segments 294-317 (294-322)
Pathways

B cell receptor signaling pathway (KEGG)

Epstein-Barr virus infection (KEGG)

Hematopoietic cell lineage (KEGG)

Immune System (Reactome)

PI3K-Akt signaling pathway (KEGG)

Primary immunodeficiency (KEGG)

Signal Transduction (Reactome)

PDB none
OPM none
Complexes none
Interactions

BTLA, Complex: CD79A:CD19:CD79B:BTLA

CD22, Complex: CD19:CD22, PubMed

CD79A, Complex: CD19:CD79A, PubMed

CD79B, Complex: CD19:CD79B, PubMed

CR2, Complex: CR2:CD81:CD19:IFM1, PubMed

IGHD, Complex: CD19:IGHD

IGHM, Complex: CD19:RFTN1:IGHM:ARI3A:GTF2I:BTK

Domains

AA: 15-115, Immunoglobulin domain

UniProt annotation for CD19_HUMAN » B-lymphocyte antigen CD19
FUNCTION: Assembles with the antigen receptor of B-lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

SUBUNIT: Forms a complex with CD21, CD81 and CD225 in the membrane of mature B-cells. Interacts with VAV. Interacts with GRB2 and SOS when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with PLCG2 when phosphorylated on Tyr-409. Interacts with LYN.

DISEASE: Immunodeficiency, common variable, 3 (CVID3) OMIM: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. mutations affecting the gene represented in this entry.

UniProt features for CD19_HUMAN » B-lymphocyte antigen CD19
SIGNAL 1 19 Potential.
CHAIN 20 556 B-lymphocyte antigen CD19.
DOMAIN 20 113 Ig-like C2-type 1.
DOMAIN 176 277 Ig-like C2-type 2.
DISULFID 38 97 Potential.
DISULFID 200 261 Potential.
Amino Acid Sequence for CD19_HUMAN » B-lymphocyte antigen CD19
MPPPRLLFFL LFLTPMEVRP EEPLVVKVEE GDNAVLQCLK GTSDGPTQQL TWSRESPLKP FLKLSLGLPG LGIHMRPLAI WLFIFNVSQQ MGGFYLCQPG PPSEKAWQPG WTVNVEGSGE LFRWNVSDLG GLGCGLKNRS SEGPSSPSGK LMSPKLYVWA KDRPEIWEGE PPCLPPRDSL NQSLSQDLTM APGSTLWLSC GVPPDSVSRG PLSWTHVHPK GPKSLLSLEL KDDRPARDMW VMETGLLLPR ATAQDAGKYY CHRGNLTMSF HLEITARPVL WHWLLRTGGW KVSAVTLAYL IFCLCSLVGI LHLQRALVLR RKRKRMTDPT RRFFKVTPPP GSGPQNQYGN VLSLPTPTSG LGRAQRWAAG LGGTAPSYGN PSSDVQADGA LGSRSPPGVG PEEEEGEGYE EPDSEEDSEF YENDSNLGQD QLSQDGSGYE NPEDEPLGPE DEDSFSNAES YENEDEELTQ PVARTMDFLS PHGSAWDPSR EATSLGSQSY EDMRGILYAA PQLRSIRGQP GPNHEEDADS YENMDNPDGP DPAWGGGGRM GTWSTR