CD180_HUMAN » CD180 antigen

CD180_HUMAN » CD180 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD180_HUMAN » CD180 antigen » Lymphocyte antigen 64;Radioprotective 105 kDa protein;
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 41 ± 0°
ΔGtransfer -39.4 kcal/mol
ΔGfold -37.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 625-654 (620-657)
Pathways none
PDB 3b2d (A/B=24-626)
OPM none
Complexes none
Interactions none
Domains

AA: 321-382, PDBID: 3B2D, Subunit A, Seq Identity:100%, Leucine rich repeat

AA: 397-419, PDBID: 3B2D, Subunit A, Seq Identity:100%, Leucine Rich Repeat

AA: 496-546, PDBID: 3B2D, Subunit A, Seq Identity:100%, Leucine rich repeat

UniProt annotation for CD180_HUMAN » CD180 antigen
FUNCTION: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

SUBUNIT: M-shaped tetramer of two CD180-LY86 heterodimers.

TISSUE SPECIFICITY: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

UniProt features for CD180_HUMAN » CD180 antigen
SIGNAL 1 23
CHAIN 24 661 CD180 antigen.
DOMAIN 33 53 LRRNT.
REPEAT 54 75 LRR 1.
REPEAT 78 99 LRR 2.
REPEAT 102 123 LRR 3.
REPEAT 126 147 LRR 4.
REPEAT 150 171 LRR 5.
REPEAT 174 195 LRR 6.
REPEAT 201 221 LRR 7.
REPEAT 275 296 LRR 8.
REPEAT 299 320 LRR 9.
REPEAT 322 343 LRR 10.
REPEAT 346 366 LRR 11.
REPEAT 371 391 LRR 12.
REPEAT 397 418 LRR 13.
REPEAT 421 442 LRR 14.
REPEAT 446 466 LRR 15.
REPEAT 470 493 LRR 16.
REPEAT 497 518 LRR 17.
REPEAT 521 544 LRR 18.
REPEAT 546 564 LRR 19.
DOMAIN 577 627 LRRCT.
Amino Acid Sequence for CD180_HUMAN » CD180 antigen
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI NLSLNFNGNN VKGIELGAFD STVFQSLNFG GTPNLSVIFN GLQNSTTQSL WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV KYLLRWKYQH I