CD166_HUMAN » CD166 antigen

CD166_HUMAN » CD166 antigen
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CD166_HUMAN » CD166 antigen » Activated leukocyte cell adhesion molecule;
Hydrophobic Thickness 32.4 ± 4.2 Å
Tilt Angle 33 ± 0°
ΔGtransfer -25.2 kcal/mol
ΔGfold -23.8 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology Out
TM Segments 526-550 (524-558)
Pathways

Cell adhesion molecules (KEGG)

Developmental Biology (Reactome)

PDB none
OPM none
Complexes none
Interactions

CD6, Complex: CD6:CD166, PubMed

EGFR, Complex: EGFR:CD166, PubMed

Domains

AA: 137-231, PDBID: 5A2F, Subunit A, Seq Identity:100%, CD80-like C2-set immunoglobulin domain

AA: 249-316, PDBID: 4W4O, Subunit C, Seq Identity:34%, Immunoglobulin domain

UniProt annotation for CD166_HUMAN » CD166 antigen
FUNCTION: Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.

TISSUE SPECIFICITY: Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines.

DOMAIN: The CD6 binding site is located in the N-terminal Ig-like domain.

UniProt features for CD166_HUMAN » CD166 antigen
SIGNAL 1 27 Potential.
CHAIN 28 583 CD166 antigen.
DOMAIN 28 120 Ig-like V-type 1.
DOMAIN 125 234 Ig-like V-type 2.
DOMAIN 245 328 Ig-like C2-type 1.
DOMAIN 333 409 Ig-like C2-type 2.
DOMAIN 416 501 Ig-like C2-type 3.
DISULFID 43 113 Potential.
DISULFID 157 220 Potential.
DISULFID 270 313 Potential.
DISULFID 354 392 Potential.
DISULFID 435 485 Potential.
Amino Acid Sequence for CD166_HUMAN » CD166 antigen
MESKGASSCR LLFCLLISAT VFRPGLGWYT VNSAYGDTII IPCRLDVPQN LMFGKWKYEK PDGSPVFIAF RSSTKKSVQY DDVPEYKDRL NLSENYTLSI SNARISDEKR FVCMLVTEDN VFEAPTIVKV FKQPSKPEIV SKALFLETEQ LKKLGDCISE DSYPDGNITW YRNGKVLHPL EGAVVIIFKK EMDPVTQLYT MTSTLEYKTT KADIQMPFTC SVTYYGPSGQ KTIHSEQAVF DIYYPTEQVT IQVLPPKNAI KEGDNITLKC LGNGNPPPEE FLFYLPGQPE GIRSSNTYTL TDVRRNATGD YKCSLIDKKS MIASTAITVH YLDLSLNPSG EVTRQIGDAL PVSCTISASR NATVVWMKDN IRLRSSPSFS SLHYQDAGNY VCETALQEVE GLKKRESLTL IVEGKPQIKM TKKTDPSGLS KTIICHVEGF PKPAIQWTIT GSGSVINQTE ESPYINGRYY SKIIISPEEN VTLTCTAENQ LERTVNSLNV SAISIPEHDE ADEISDENRE KVNDQAKLIV GIVVGLLLAA LVAGVVYWLY MKKSKTASKH VNKDLGNMEE NKKLEENNHK TEA