CCPG1_HUMAN » Cell cycle progression protein 1

CCPG1_HUMAN » Cell cycle progression protein 1
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CCPG1_HUMAN » Cell cycle progression protein 1 » Cell cycle progression restoration protein 8;
Hydrophobic Thickness 32.2 ± 2.0 Å
Tilt Angle 16 ± 0°
ΔGtransfer -15.2 kcal/mol
ΔGfold -13.4 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 217-238 (217-243)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains none
UniProt annotation for CCPG1_HUMAN » Cell cycle progression protein 1
FUNCTION: Acts as an assembly platform for Rho protein signaling complexes. Limits guanine nucleotide exchange activity of MCF2L toward RHOA, which results in an inhibition of both its transcriptional activation ability and its transforming activity. Does not inhibit activity of MCF2L toward CDC42, or activity of MCF2 toward either RHOA or CDC42 (By similarity). May be involved in cell cycle regulation.

SUBUNIT: Interacts with MCF2L. May interact with MCF2, ARHGEF1, BCR, VAV1 and FGD1, but not with TIAM1. Interacts with GTP-bound CDC42 and SRC (By similarity).

UniProt features for CCPG1_HUMAN » Cell cycle progression protein 1
CHAIN 1 757 Cell cycle progression protein 1.
REGION 1 308 Interaction with MCF2L and SRC (By similarity).
COILED 248 272 Potential.
COILED 306 450 Potential.
COILED 504 530 Potential.
Amino Acid Sequence for CCPG1_HUMAN » Cell cycle progression protein 1
MSENSSDSDS SCGWTVISHE GSDIEMLNSV TPTDSCEPAP ECSSLEQEEL QALQIEQGES SQNGTVLMEE TAYPALEETS STIEAEEQKI PEDSIYIGTA SDDSDIVTLE PPKLEEIGNQ EVVIVEEAQS SEDFNMGSSS SSQYTFCQPE TVFSSQPSDD ESSSDETSNQ PSPAFRRRRA RKKTVSASES EDRLVAEQET EPSKELSKRQ FSSGLNKCVI LALVIAISMG FGHFYGTIQI QKRQQLVRKI HEDELNDMKD YLSQCQQEQE SFIDYKSLKE NLARCWTLTE AEKMSFETQK TNLATENQYL RVSLEKEEKA LSSLQEELNK LREQIRILED KGTSTELVKE NQKLKQHLEE EKQKKHSFLS QRETLLTEAK MLKRELERER LVTTALRGEL QQLSGSQLHG KSDSPNVYTE KKEIAILRER LTELERKLTF EQQRSDLWER LYVEAKDQNG KQGTDGKKKG GRGSHRAKNK SKETFLGSVK ETFDAMKNST KEFVRHHKEK IKQAKEAVKE NLKKFSDSVK STFRHFKDTT KNIFDEKGNK RFGATKEAAE KPRTVFSDYL HPQYKAPTEN HHNRGPTMQN DGRKEKPVHF KEFRKNTNSK KCSPGHDCRE NSHSFRKACS GVFDCAQQES MSLFNTVVNP IRMDEFRQII QRYMLKELDT FCHWNELDQF INKFFLNGVF IHDQKLFTDF VNDVKDYLRN MKEYEVDNDG VFEKLDEYIY RHFFGHTFSP PYGPRSVYIK PCHYSSL