CC14C_HUMAN » Dual specificity protein phosphatase CDC14C

CC14C_HUMAN » Dual specificity protein phosphatase CDC14C
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Topology in Nuclear membrane
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CC14C_HUMAN » Dual specificity protein phosphatase CDC14C » CDC14 cell division cycle 14 homolog C;
Hydrophobic Thickness 32.8 ± 2.9 Å
Tilt Angle 5 ± 4°
ΔGtransfer -20.1 kcal/mol
ΔGfold -10.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 526-548 (525-549)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 128-266, PDBID: 1OHC, Subunit A, Seq Identity:95%, Dual specificity protein phosphatase, N-terminal half

AA: 317-443, PDBID: 1OHC, Subunit A, Seq Identity:99%, Dual specificity phosphatase, catalytic domain

UniProt annotation for CC14C_HUMAN » Dual specificity protein phosphatase CDC14C
FUNCTION: Dual-specificity phosphatase. Preferentially dephosphorylates proteins modified by proline-directed kinases (By similarity).

CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.

CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O = [a protein]-serine/threonine + phosphate.

DOMAIN: Composed of two structurally equivalent A and B domains that adopt a dual specificity protein phosphatase (DSP) fold.

MISCELLANEOUS: May act as an autosomal functional substitute.

UniProt features for CC14C_HUMAN » Dual specificity protein phosphatase CDC14C
CHAIN 1 554 Dual specificity protein phosphatase CDC14C.
REGION 121 275 A (By similarity).
REGION 276 289 Linker (By similarity).
REGION 290 456 B (By similarity).
MOTIF 78 131 Nucleolar localization signal (By similarity).
Amino Acid Sequence for CC14C_HUMAN » Dual specificity protein phosphatase CDC14C
MNEVSSECGK KCEPLGCSST NGDLQGEAGA VVSIFLRMVP RIKSNEGYGY SNRNWRKENT MHSLDRNIVD GGQALGQWKR KSKGRSSWAA APLCSQRCSL TLQGVKKMRS STLQDPRRWD PQDDVYLDIT DRLRFAILYS RPKSASNVHY FSIDNELEYE NFSEDFGPLN LAMVYRYCCK INKKLKSITM LRKKIVHFTG SDQRKQANAA FLVGCYMVIY LGRTPEAAYR ILIFGDTPYI PFRDAAYGSC NFYITLLDCF HAVKKAMQYG FLNFNSFNLD EYEHYEKAEN GDLNWIIPDR FIAFCGPHSR ARLESGYHQH SPETYIQYFK NHNVTTIIRL NKRMYDAKRF TDAGFDHHDL FFADGSTPTD AIVKRFLDIC ENAEGAIAVH CKAGLGRTGT LIACYIMKHY RMTAAETIAW VRICRPGLVI GPQQQFLVMK QTSLWLEGDY FRQKLKGQEN GQHRAAFSKL LSGVDDISIN GVENQDQQEP KPYGDDDEIN GVTQGDRSRA LKRRRQSKTN DILLPSPLAV LTFTLCSVVI WWIVCDYILP ILLF