CBLN2_HUMAN » Cerebellin-2

CBLN2_HUMAN » Cerebellin-2
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Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CBLN2_HUMAN » Cerebellin-2 »
Hydrophobic Thickness 29.6 ± 3.4 Å
Tilt Angle 1 ± 5°
ΔGtransfer -17.7 kcal/mol
ΔGfold -9.2 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC
Topology In
TM Segments 30-50 (30-52)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 94-221, PDBID: 4OUL, Subunit D, Seq Identity:41%, C1q domain

UniProt annotation for CBLN2_HUMAN » Cerebellin-2
FUNCTION: May play role in synaptogenesis induction.

SUBUNIT: May form homooligomers or heterooligomers with CBLN1 and CBLN3 prior to secretion. Once secreted, does not interact with other CBLN family members. Interacts with GRID2, and more weakly with GRID1. Interacts with NRXN1 and NRXN2 long and short isoforms produced by alternative promoter usage. Weakly interacts with NRXN3 short isoform and not at all with NRXN3 long isoform (By similarity).

UniProt features for CBLN2_HUMAN » Cerebellin-2
CHAIN 1 224 Cerebellin-2.
DOMAIN 88 224 C1q.
Amino Acid Sequence for CBLN2_HUMAN » Cerebellin-2
MQAPGRGPLG LRLMMPGRRG ALREPGGCGS CLGVALALLL LLLPACCPVR AQNDTEPIVL EGKCLVVCDS SPSADGAVTS SLGISVRSGS AKVAFSATRS TNHEPSEMSN RTMTIYFDQV LVNIGNHFDL ASSIFVAPRK GIYSFSFHVV KVYNRQTIQV SLMQNGYPVI SAFAGDQDVT REAASNGVLL LMEREDKVHL KLERGNLMGG WKYSTFSGFL VFPL