CALY_HUMAN » Neuron-specific vesicular protein calcyon

CALY_HUMAN » Neuron-specific vesicular protein calcyon
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Topology in Vesicle membrane
Topologyvesicle lumenal side
cytoplasmic side
CALY_HUMAN » Neuron-specific vesicular protein calcyon »
Hydrophobic Thickness 30.8 ± 3.2 Å
Tilt Angle 7 ± 11°
ΔGtransfer -21.9 kcal/mol
ΔGfold -14.6 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology In
TM Segments 85-106 (84-111)
Pathways

Dopaminergic synapse (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 1-181, D1 dopamine receptor-interacting protein (calcyon)

UniProt annotation for CALY_HUMAN » Neuron-specific vesicular protein calcyon
FUNCTION: Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis.

SUBUNIT: Interacts with CLTA.

TISSUE SPECIFICITY: Expressed in the pyramidal cells of the prefrontal cortex, in hippothalamus and in caudate nucleus. No expression in spleen. Up-regulated in the prefrontal cortex of schizophrenic patients with nearly twice the levels of non- schizophrenics.

UniProt features for CALY_HUMAN » Neuron-specific vesicular protein calcyon
CHAIN 1 217 Neuron-specific vesicular protein calcyon.
Amino Acid Sequence for CALY_HUMAN » Neuron-specific vesicular protein calcyon
MVKLGCSFSG KPGKDPGDQD GAAMDSVPLI SPLDISQLQP PLPDQVVIKT QTEYQLSSPD QQNFPDLEGQ RLNCSHPEEG RRLPTARMIA FAMALLGCVL IMYKAIWYDQ FTCPDGFLLR HKICTPLTLE MYYTEMDPER HRSILAAIGA YPLSRKHGTE TPAAWGDGYR AAKEERKGPT QAGAAAAATE PPGKPSAKAE KEAARKAAGS AAPPPAQ