CALX_YEAST » Calnexin homolog

CALX_YEAST » Calnexin homolog
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CALX_YEAST » Calnexin homolog »
Hydrophobic Thickness 34.2 ± 2.8 Å
Tilt Angle 18 ± 15°
ΔGtransfer -20.3 kcal/mol
ΔGfold -11.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 478-500 (478-501)
Pathways

Phagosome (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

ALG5, Complex: CALX:ALG5

ANP1, Complex: CALX:ANP1

BIG1, Complex: CALX:BIG1

COX7, Complex: CALX:COX7

CSF1, Complex: CALX:CSF1

CWH41, Complex: CALX:CWH41

ERP1, Complex: ERP1:CALX

ERP2, Complex: ERP2:CALX

GDA1, Complex: GDA1:CALX

GOSR1, Complex: CALX:GOSR1

GPI3, Complex: CALX:GPI3

GPI8, Complex: CALX:GPI8

HOC1, Complex: CALX:HOC1

HRD3, Complex: HRD3:CALX

IRE1, Complex: CALX:IRE1

KRE6, Complex: KRE6:CALX

MMM1, Complex: CALX:MMM1

MNN10, Complex: MNN10:CALX

MNN11, Complex: MNN11:CALX

MNN2, Complex: CALX:MNN2

OSTB, Complex: CALX:OSTB

PBN1, Complex: PBN1:CALX

ROT1, Complex: ROT1:CALX, PubMed

SEC66, Complex: CALX:SEC66

SLP1, Complex: CALX:SLP1

TLG2, Complex: CALX:TLG2

VOA1, Complex: CALX:VOA1

Domains

AA: 33-413, PDBID: 1JHN, Subunit A, Seq Identity:31%, Calreticulin family

UniProt annotation for CALX_YEAST » Calnexin homolog
FUNCTION: Interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins.

SUBUNIT: Interacts with MPD1.

MISCELLANEOUS: In contrast with other calnexin, yeast CNE1 does not seem to bind calcium.

MISCELLANEOUS: Present with 4760 molecules/cell in log phase SD medium.

UniProt features for CALX_YEAST » Calnexin homolog
SIGNAL 1 19 Potential.
CHAIN 20 502 Calnexin homolog.
REPEAT 250 261 1-1.
REPEAT 267 278 1-2.
REPEAT 286 297 1-3.
REPEAT 305 316 1-4.
REPEAT 320 330 2-1.
REPEAT 339 349 2-2.
REPEAT 353 363 2-3.
REPEAT 367 377 2-4.
REGION 248 381 P domain (Extended arm) (By similarity).
REGION 250 316 4 X approximate repeats.
REGION 320 377 4 X approximate repeats.
DISULFID 125 161 By similarity.
DISULFID 332 338 By similarity.
Amino Acid Sequence for CALX_YEAST » Calnexin homolog
MKFSAYLWWL FLNLALVKGT SLLSNVTLAE DSFWEHFQAY TNTKHLNQEW ITSEAVNNEG SKIYGAQWRL SQGRLQGSAW DKGIAVRTGN AAAMIGHLLE TPINVSETDT LVVQYEIKLD NSLTCGGAFI KLMSGFMNVE ALKHYAPDTE GVELVFGPDY CAPEINGVQF AINKVDKITH ESKLRYLQEM PLSKLTDTSQ SHLYTLIIDE SAQSFQILID GKTVMVREHI EDKKKVNFEP PITPPLMIPD VSVAKPHDWD DRIRIPDPEA VKLSDRDERD PLMIPHPDGT EPPEWNSSIP EYILDPNAQK PSWWKELEHG EWIPPMIKNP LCTAERGCGQ QIPGLINNAK YKGPGELNEI INPNYMGEWH PPEIENPLYY EEQHPLRIEN VISGVILEFW SGSPNMLISN IYVGKNVTEA QIIGNKTWLM RDRAFRGSDG PTERKFMNSR LGNLQTTFHN ERESPNPFDR IIDRILEQPL KFVLTAAVVL LTTSVLCCVV FT