CALX_HUMAN » Calnexin

CALX_HUMAN » Calnexin
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CALX_HUMAN » Calnexin » IP90;Major histocompatibility complex class I antigen-binding protein p88;p90;
Hydrophobic Thickness 33.2 ± 2.3 Å
Tilt Angle 4 ± 3°
ΔGtransfer -24.0 kcal/mol
ΔGfold -17.7 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, Reactome, HMDB
Topology Out
TM Segments 481-503 (479-510)
Pathways

Antigen processing and presentation (KEGG)

HTLV-I infection (KEGG)

Immune System (Reactome)

Phagosome (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions

APOA, Complex: APOA:CALX, PubMed

ASGR1, Complex: ASGR1:CALX, PubMed

CD1D, Complex: PDIA3:CD1D:CALX:CALR, PubMed

CD3D, Complex: CALX:CD3D, PubMed

CD3Z, Complex: CD3Z:CALX, PubMed

EDEM1, Complex: CALX:EDEM1, PubMed

EGFR, Complex: CALX:EGFR, PubMed

EMC1, Complex: CALX:EMC1

ERBB2, Complex: CALX:ERBB2, PubMed

ERBB3, Complex: CALX:ERBB3, PubMed

ERLN2, Complex: CALX:ERLN2

GPI8, Complex: CALX:GPI8, PubMed

HLAE, Complex: HLAF:CALX:HLAE:PDIA3:CALR:B2MG:HLAG:TPSN, PubMed

INGR1, Complex: CALX:INGR1, PubMed

ITA6, Complex: CALX:ITA6, PubMed

ITB1, Complex: CD9:ITB1:CALX, PubMed

JAG1, Complex: JAG1:CALX, PubMed

L1CAM, Complex: CALX:L1CAM, PubMed

LDLR, Complex: LDLR:CALX, PubMed

LMAN1, Complex: LMAN1:CALX, PubMed

LPH, Complex: LPH:CALX, PubMed

LRP1, Complex: CALX:LRP1, PubMed

MBTP1, Complex: MBTP1:CALX, PubMed

NPHN, Complex: NPHN:CALX

PGRC1, Complex: PGRC1:CALX, PubMed

RAGE, Complex: CALX:RAGE, PubMed

SERP1, Complex: SERP1:CALX, PubMed

SSRA, Complex: SSRA:CALX, PubMed

TMX1, Complex: CALX:TMX1

TMX2, Complex: CALX:TMX2

TMX3, Complex: CALX:TMX3

TMX4, Complex: CALX:TMX4

TNR1A, Complex: TNR1A:CALX, PubMed

TOM20, Complex: TOM20:CALX, PubMed

UBP19, Complex: UBP19:CALX

XBP1, Complex: CALX:XBP1, PubMed

ZNRF4, Complex: CALX:ZNRF4, PubMed

Domains

AA: 71-440, PDBID: 1JHN, Subunit A, Seq Identity:96%, Calreticulin family

UniProt annotation for CALX_HUMAN » Calnexin
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor- mediated endocytosis at the synapse.

SUBUNIT: Interacts with MAPK3/ERK1. Interacts with KCNH2. Associates with ribosomes. Interacts with SGIP1; involved in negative regulation of endocytosis (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins. Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1. Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELK, STT3A, VCP AND VIMP. Interacts with PPIB.

UniProt features for CALX_HUMAN » Calnexin
SIGNAL 1 20 Potential.
CHAIN 21 592 Calnexin.
REPEAT 278 290 1-1.
REPEAT 295 307 1-2.
REPEAT 314 326 1-3.
REPEAT 333 345 1-4.
REPEAT 348 358 2-1.
REPEAT 367 377 2-2.
REPEAT 381 391 2-3.
REPEAT 395 405 2-4.
REGION 276 409 P domain (Extended arm) (By similarity).
REGION 278 345 4 X approximate repeats.
REGION 348 405 4 X approximate repeats.
REGION 503 592 Sufficient to mediate interaction with SGIP1 (By similarity).
DISULFID 160 194 By similarity.
DISULFID 360 366 By similarity.
Amino Acid Sequence for CALX_HUMAN » Calnexin
MEGKWLLCML LVLGTAIVEA HDGHDDDVID IEDDLDDVIE EVEDSKPDTT APPSSPKVTY KAPVPTGEVY FADSFDRGTL SGWILSKAKK DDTDDEIAKY DGKWEVEEMK ESKLPGDKGL VLMSRAKHHA ISAKLNKPFL FDTKPLIVQY EVNFQNGIEC GGAYVKLLSK TPELNLDQFH DKTPYTIMFG PDKCGEDYKL HFIFRHKNPK TGIYEEKHAK RPDADLKTYF TDKKTHLYTL ILNPDNSFEI LVDQSVVNSG NLLNDMTPPV NPSREIEDPE DRKPEDWDER PKIPDPEAVK PDDWDEDAPA KIPDEEATKP EGWLDDEPEY VPDPDAEKPE DWDEDMDGEW EAPQIANPRC ESAPGCGVWQ RPVIDNPNYK GKWKPPMIDN PSYQGIWKPR KIPNPDFFED LEPFRMTPFS AIGLELWSMT SDIFFDNFII CADRRIVDDW ANDGWGLKKA ADGAAEPGVV GQMIEAAEER PWLWVVYILT VALPVFLVIL FCCSGKKQTS GMEYKKTDAP QPDVKEEEEE KEEEKDKGDE EEEGEEKLEE KQKSDAEEDG GTVSQEEEDR KPKAEEDEIL NRSPRNRKPR RE