CALX2_ARATH » Calnexin homolog 2

CALX2_ARATH » Calnexin homolog 2
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Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CALX2_ARATH » Calnexin homolog 2 »
Hydrophobic Thickness 32.4 ± 2.8 Å
Tilt Angle 27 ± 12°
ΔGtransfer -23.5 kcal/mol
ΔGfold -17.3 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 467-491 (467-493)
Pathways none
PDB none
OPM none
Complexes none
Interactions

Y2182, Complex: Y2182:CALX2

Y2289, Complex: Y2289:CALX2

Domains

AA: 31-388, PDBID: 1JHN, Subunit A, Seq Identity:48%, Calreticulin family

UniProt annotation for CALX2_ARATH » Calnexin homolog 2
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
UniProt features for CALX2_ARATH » Calnexin homolog 2
SIGNAL 1 25 Potential.
CHAIN 26 532 Calnexin homolog 2.
REPEAT 227 238 1-1.
REPEAT 244 255 1-2.
REPEAT 263 274 1-3.
REPEAT 282 293 1-4.
REPEAT 297 307 2-1.
REPEAT 316 326 2-2.
REPEAT 330 340 2-3.
REPEAT 344 354 2-4.
REGION 225 358 P domain (Extended arm) (By similarity).
REGION 227 293 4 X approximate repeats.
REGION 297 354 4 X approximate repeats.
DISULFID 110 145 By similarity.
DISULFID 309 315 By similarity.
Amino Acid Sequence for CALX2_ARATH » Calnexin homolog 2
MRERIITFVS LLLVALLSFP SVSYCDDQTI LYESFDEPFD GRWVVSEKAE YQGVWKHEKS EGHDDYGLLV SEKAKKYGIV KELDVDEPLN LNEGTVVLQY EARFQEGLEC GGAYLKYLRP QEAGWVPQGF DNDSPYSIMF GPDKCGATNK VHFILKHKNP KSGEFVEHHL KFPPSVPFDM LSHVYTAVLK SDNEVRILVD GEEKKKGNLL SAEDFEPPLI PSKTIPDPED KKPEDWDERA KIPDPNAVKP DDWDEDAPME IEDEEAEKPE GWLDDEPVEV EDPEASKPED WDDEEDGEWE APKVSNTKCE AAPGCGEWKR PMKRNPAYKG KWSSPLIDNP AYKGIWKPRD IPNPDYFELE RPNLEPIAAI GIEIWTMQDG ILFDNILISK DEKVAETYRQ STWKPKFDVE KEKQKAEDEA AGEADGLKSY QKKVFDLLYK VADISFLSAY KSKIMELIEK AETQPNLTIG VLISIVIVFL SLFFKLIFGG AKAKVEKKKP ETAAETSTSE AKTEEKAEAV AAPRKRQTRR ES