CALX1_ARATH » Calnexin homolog 1

CALX1_ARATH » Calnexin homolog 1
Magnify CALX1_ARATH » Calnexin homolog 1Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Endoplasmic reticulum membrane
Topologylumenal side
cytoplasmic side
CALX1_ARATH » Calnexin homolog 1 »
Hydrophobic Thickness 34.4 ± 3.6 Å
Tilt Angle 1 ± 0°
ΔGtransfer -25.2 kcal/mol
ΔGfold -19.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING
Topology Out
TM Segments 465-488 (465-493)
Pathways

Phagosome (KEGG)

Protein processing in endoplasmic reticulum (KEGG)

PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 31-386, PDBID: 1JHN, Subunit A, Seq Identity:50%, Calreticulin family

UniProt annotation for CALX1_ARATH » Calnexin homolog 1
FUNCTION: Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins (By similarity).
UniProt features for CALX1_ARATH » Calnexin homolog 1
SIGNAL 1 20 Potential.
CHAIN 21 530 Calnexin homolog 1.
REPEAT 225 236 1-1.
REPEAT 242 253 1-2.
REPEAT 261 272 1-3.
REPEAT 280 291 1-4.
REPEAT 295 305 2-1.
REPEAT 314 324 2-2.
REPEAT 328 338 2-3.
REPEAT 342 352 2-4.
REGION 223 356 P domain (Extended arm) (By similarity).
REGION 225 291 4 X approximate repeats.
REGION 295 352 4 X approximate repeats.
DISULFID 108 143 By similarity.
DISULFID 307 313 By similarity.
Amino Acid Sequence for CALX1_ARATH » Calnexin homolog 1
MRQRQLFSVF LLLLAFVSFQ KLCYCDDQTV LYESFDEPFD GRWIVSKNSD YEGVWKHAKS EGHEDYGLLV SEKARKYGIV KELDEPLNLK EGTVVLQYEV RFQEGLECGG AYLKYLRPQE AGWTPQGFDS ESPYSIMFGP DKCGGTNKVH FILKHKNPKS GEYVEHHLKF PPSVPYDKLS HVYTAILKPD NEVRILVDGE EKKKANLLSG EDFEPALIPA KTIPDPEDKK PEDWDERAKI PDPNAVKPED WDEDAPMEIE DEEAEKPEGW LDDEPEEVDD PEATKPEDWD DEEDGMWEAP KIDNPKCEAA PGCGEWKRPM KRNPAYKGKW SSPLIDNPAY KGIWKPRDIP NPDYFELDRP DYEPIAAIGI EIWTMQDGIL FDNILIAKDE KVAETYRQTT WKPKFDVEKE KQKAEEEAAG SADGLKSYQK VVFDLLNKVA DLSFLSAYKS KITELIEKAE QQPNLTIGVL VAIVVVFFSL FLKLIFGGKK AAAPVEKKKP EVAESSKSGD EAEKKEETAA PRKRQPRRDN