CADM4_HUMAN » Cell adhesion molecule 4

CADM4_HUMAN » Cell adhesion molecule 4
Magnify CADM4_HUMAN » Cell adhesion molecule 4Enlarged view of image
3D view in GLMol or JMol

gray dot

Download Coordinates

gray dot

Topology in Plasma membrane
Topologyextracellular side
cytoplasmic side
CADM4_HUMAN » Cell adhesion molecule 4 » Immunoglobulin superfamily member 4C;IgSF4C; Nectin-like protein 4;NECL-4; TSLC1-like protein 2;
Hydrophobic Thickness 41.2 ± 1.6 Å
Tilt Angle 0 ± 2°
ΔGtransfer -56.3 kcal/mol
ΔGfold -23.0 kcal/mol
Links UniProtKB, Pfam, Interpro, iHOP, STRING, HGNC, HMDB
Topology Out
TM Segments 321-349 (320-352)
Pathways none
PDB none
OPM none
Complexes none
Interactions none
Domains

AA: 27-123, PDBID: 4H5S, Subunit B, Seq Identity:42%, Immunoglobulin V-set domain

AA: 122-210, PDBID: 4OFY, Subunit F, Seq Identity:31%, CD80-like C2-set immunoglobulin domain

AA: 223-295, PDBID: 1CS6, Subunit A, Seq Identity:34%, Immunoglobulin domain

UniProt annotation for CADM4_HUMAN » Cell adhesion molecule 4
FUNCTION: Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity.

SUBUNIT: Monomer and homodimer.

TISSUE SPECIFICITY: Expressed in brain, prostate, brain, kidney and some other organs.

UniProt features for CADM4_HUMAN » Cell adhesion molecule 4
SIGNAL 1 20 Potential.
CHAIN 21 388 Cell adhesion molecule 4.
DOMAIN 21 119 Ig-like V-type.
DOMAIN 124 219 Ig-like C2-type 1.
DOMAIN 224 307 Ig-like C2-type 2.
DISULFID 44 104 By similarity.
DISULFID 145 199 By similarity.
DISULFID 245 291 By similarity.
Amino Acid Sequence for CADM4_HUMAN » Cell adhesion molecule 4
MGRARRFQWP LLLLWAAAAG PGAGQEVQTE NVTVAEGGVA EITCRLHQYD GSIVVIQNPA RQTLFFNGTR ALKDERFQLE EFSPRRVRIR LSDARLEDEG GYFCQLYTED THHQIATLTV LVAPENPVVE VREQAVEGGE VELSCLVPRS RPAATLRWYR DRKELKGVSS SQENGKVWSV ASTVRFRVDR KDDGGIIICE AQNQALPSGH SKQTQYVLDV QYSPTARIHA SQAVVREGDT LVLTCAVTGN PRPNQIRWNR GNESLPERAE AVGETLTLPG LVSADNGTYT CEASNKHGHA RALYVLVVYD PGAVVEAQTS VPYAIVGGIL ALLVFLIICV LVGMVWCSVR QKGSYLTHEA SGLDEQGEAR EAFLNGSDGH KRKEEFFI